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- W2023019213 abstract "Abstract An alkoxybenzylidene acetal linker formed with the 2′- and 3′-OH of the 3′-terminal ribonucleoside and attached to the solid support through an amide bond fulfills the necessary requirements of base stability and acid lability to be used in solid phase oligoribonucleotide synthesis in combination with Fmoc and Mthp groups for 5′-OH and 2′-OH protection respectively. Methyl protected phosphates do not give rise to N-methylation of pyrimidine bases (T or U) when piperidine, instead of DBU, is used to remove the Fmoc groups." @default.
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- W2023019213 date "1993-03-01" @default.
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- W2023019213 title "An acid-labile linker for solid-phase oligoribonucleotide synthesis using Fmoc group for 5′-hydroxyl protection" @default.
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