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- W2023019653 abstract "Four-wave mixing is presented as an ultrasensitive detection method for liquid analytes in capillary flow cells and for circular dichroism measurements. A two-input-beam forward- scattering degenerate four-wave mixing optical setup offers simplified optical alignment, effective use of compact low-power lasers, and convenient interface to powerful chemical separation methods using capillary columns. The use of a single focusing lens for both input beams provides very high wave-mixing efficiency and tight focusing inside a small detection probe volume. Attomole or better detection sensitivity levels of this nonlinear laser detector compare favorably to those of many conventional laser-based analytical methods, yet this nonlinear detector can detect both fluorescing and non-fluorescing analytes. One can conveniently interface this multi-wave mixing detector to liquid chromatography and capillary electrophoresis for on-column detection. Nonlinear wave-mixing as a sensitive `direct' or `indirect' absorbance detection method offers important advantages in many biomedical applications." @default.
- W2023019653 created "2016-06-24" @default.
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- W2023019653 date "1995-05-08" @default.
- W2023019653 modified "2023-09-23" @default.
- W2023019653 title "<title>Sensitive laser wave-mixing detection methods for biomedical applications</title>" @default.
- W2023019653 doi "https://doi.org/10.1117/12.208479" @default.
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