FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023019714> ?p ?o ?g. }

• W2023019714 endingPage "111" @default.
• W2023019714 startingPage "93" @default.
• W2023019714 abstract "Atherosclerosis preferentially occurs in areas of turbulent flow and low fluid shear stress, whereas laminar flow and high shear stress are atheroprotective. Inflammatory cytokines, such as tumor necrosis factor-alpha (TNF), have been shown to stimulate expression of endothelial cell (EC) genes that may promote atherosclerosis. Recent data suggest that steady laminar flow decreases EC apoptosis and blocks TNF-mediated EC activation. EC apoptosis is likely important in the process termed plaque erosion that leads to platelet aggregation. Steady laminar flow inhibits EC apoptosis by preventing cell cycle entry, by increasing antioxidant mechanisms (e.g., superoxide dismutase), and by stimulating nitric oxide-dependent protective pathways that involve enzymes PI3-kinase and Akt. Conversely, our laboratory has identified nitric oxide-independent mechanisms that limit TNF signal transduction. TNF regulates gene expression in EC, in part, by stimulating mitogen-activated protein kinases (MAPK) which phosphorylate transcription factors. We hypothesized that fluid shear stress modulates TNF effects on EC by inhibiting TNF-mediated activation of MAP kinases. To test this hypothesis, we determined the effects of steady laminar flow (shear stress = 12 dynes/cm2) on TNF-stimulated activity of two MAP kinases: extracellular signal regulated kinase (ERK1/2) and c-Jun N-terminal kinase (JNK). Flow alone stimulated ERK1/2 activity, but decreased JNK activity compared to static controls. TNF (10 ng/ml) alone activated both ERK1/2 and JNK maximally at 15 minutes in human umbilical vein EC (HUVEC). Pre-exposing HUVEC for 10 minutes to flow inhibited TNF activation of JNK by 46%, but it had no significant effect on ERK1/2 activation. Incubation of EC with PD98059, a specific mitogen-activated protein kinase kinase inhibitor, blocked the flow-mediated inhibition of TNF activation of JNK. Flow-mediated inhibition of JNK was unaffected by 0.1 mM L-nitroarginine, 100 pM 8-bromo-cyclic GMP, or 100 microM 8-bromo-cyclic AMP. Transfection studies with dominant negative constructs of the protein kinase MEK1 and MEK5 suggested an important role for BMK1 in flow-mediated regulation of TNF signals. In summary, the atheroprotective effects of steady laminar flow on the endothelium involve multiple synergistic mechanisms." @default.
• W2023019714 created "2016-06-24" @default.
• W2023019714 creator A5003632963 @default.
• W2023019714 creator A5005886470 @default.
• W2023019714 creator A5015102287 @default.
• W2023019714 creator A5034101987 @default.
• W2023019714 creator A5055245284 @default.
• W2023019714 date "2008-09-22" @default.
• W2023019714 modified "2023-10-03" @default.
• W2023019714 title "Endothelial Atheroprotective and Anti-inflammatory Mechanisms" @default.
• W2023019714 cites W1540295714 @default.
• W2023019714 cites W1575383081 @default.
• W2023019714 cites W1619653867 @default.
• W2023019714 cites W1969268163 @default.
• W2023019714 cites W1969393277 @default.
• W2023019714 cites W1970885630 @default.
• W2023019714 cites W1973614704 @default.
• W2023019714 cites W1976385326 @default.
• W2023019714 cites W1984903682 @default.
• W2023019714 cites W1986559713 @default.
• W2023019714 cites W1987403356 @default.
• W2023019714 cites W1988431963 @default.
• W2023019714 cites W1990250600 @default.
• W2023019714 cites W1995293968 @default.
• W2023019714 cites W1997454000 @default.
• W2023019714 cites W1998979756 @default.
• W2023019714 cites W2000551500 @default.
• W2023019714 cites W2006184287 @default.
• W2023019714 cites W2007417655 @default.
• W2023019714 cites W2008872627 @default.
• W2023019714 cites W2012357103 @default.
• W2023019714 cites W2014446732 @default.
• W2023019714 cites W2015535533 @default.
• W2023019714 cites W2017084799 @default.
• W2023019714 cites W2019104763 @default.
• W2023019714 cites W2019978702 @default.
• W2023019714 cites W2024237589 @default.
• W2023019714 cites W2034580062 @default.
• W2023019714 cites W2046933787 @default.
• W2023019714 cites W2047604959 @default.
• W2023019714 cites W2052055930 @default.
• W2023019714 cites W2052364512 @default.
• W2023019714 cites W2055855948 @default.
• W2023019714 cites W2056823054 @default.
• W2023019714 cites W2060141022 @default.
• W2023019714 cites W2061530710 @default.
• W2023019714 cites W2064122617 @default.
• W2023019714 cites W2064439294 @default.
• W2023019714 cites W2065577350 @default.
• W2023019714 cites W2067042723 @default.
• W2023019714 cites W2071055800 @default.
• W2023019714 cites W2072873516 @default.
• W2023019714 cites W2083217753 @default.
• W2023019714 cites W2087867044 @default.
• W2023019714 cites W2090193716 @default.
• W2023019714 cites W2097070591 @default.
• W2023019714 cites W2104078373 @default.
• W2023019714 cites W2104324075 @default.
• W2023019714 cites W2116063836 @default.
• W2023019714 cites W2118814154 @default.
• W2023019714 cites W2124149576 @default.
• W2023019714 cites W2130191536 @default.
• W2023019714 cites W2133203551 @default.
• W2023019714 cites W2146831679 @default.
• W2023019714 cites W2147367812 @default.
• W2023019714 cites W2148206240 @default.
• W2023019714 cites W2157004216 @default.
• W2023019714 cites W2160301642 @default.
• W2023019714 cites W2162010936 @default.
• W2023019714 cites W2324841714 @default.
• W2023019714 cites W281562630 @default.
• W2023019714 doi "https://doi.org/10.1111/j.1749-6632.2001.tb03932.x" @default.
• W2023019714 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11795313" @default.
• W2023019714 hasPublicationYear "2008" @default.
• W2023019714 type Work @default.
• W2023019714 sameAs 2023019714 @default.
• W2023019714 citedByCount "201" @default.
• W2023019714 countsByYear W20230197142012 @default.
• W2023019714 countsByYear W20230197142013 @default.
• W2023019714 countsByYear W20230197142014 @default.
• W2023019714 countsByYear W20230197142015 @default.
• W2023019714 countsByYear W20230197142016 @default.
• W2023019714 countsByYear W20230197142017 @default.
• W2023019714 countsByYear W20230197142018 @default.
• W2023019714 countsByYear W20230197142019 @default.
• W2023019714 countsByYear W20230197142020 @default.
• W2023019714 countsByYear W20230197142021 @default.
• W2023019714 countsByYear W20230197142022 @default.
• W2023019714 countsByYear W20230197142023 @default.
• W2023019714 crossrefType "journal-article" @default.
• W2023019714 hasAuthorship W2023019714A5003632963 @default.
• W2023019714 hasAuthorship W2023019714A5005886470 @default.
• W2023019714 hasAuthorship W2023019714A5015102287 @default.
• W2023019714 hasAuthorship W2023019714A5034101987 @default.
• W2023019714 hasAuthorship W2023019714A5055245284 @default.
• W2023019714 hasConcept C132149769 @default.
• W2023019714 hasConcept C134018914 @default.
• W2023019714 hasConcept C153911025 @default.

• next