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- W2023019960 abstract "The distribution of the prohormone convertases, PC1/3, PC2 and PC5/6, was determined by immunoblotting in two cell lines. In alpha TC1-6 cells, the proglucagon processing occurred according to the pancreatic A-cell type. In STC-1 cells, proglucagon was processed in a manner reminiscent of the intestinal L-cell type. PC1/3 was undetectable in both proglucagon processing cell lines whereas PC2 displayed a strong immunostaining in the alpha TC1-6 cells and was barely detectable in the STC-1 cells. PC5/6 was detected as a 70 kDa protein in both cell lines. These results suggest a possible role of PC2 in the processing of proglucagon into glucagon in the A-cells, whereas in L-cells it would require still undetermined endoproteases." @default.
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- W2023019960 date "1994-05-09" @default.
- W2023019960 modified "2023-10-14" @default.
- W2023019960 title "Immunological detection of prohormone convertases in two different proglucagon processing cell lines" @default.
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- W2023019960 doi "https://doi.org/10.1016/0014-5793(94)00371-8" @default.
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