FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023021110> ?p ?o ?g. }

• W2023021110 endingPage "521" @default.
• W2023021110 startingPage "514" @default.
• W2023021110 abstract "We previously reported that bone morphogenetic protein 4/drosophila mothers against decapentaplegic protein (BMP4/Smad) signalling pathway initiated primordial follicle growth and prevented oocyte apoptosis via up-regulation of Sohlh2 and receptor for kit ligand (c-kit). The mechanism underlying this process was not fully elucidated. In the present study, primary oocyte cultures were established from ovaries of 3-day-old female mouse pups by two-step enzyme digestion. Cultures were divided into Sohlh2 small interference RNA (SiRNA) group, negative SiRNA group, Sohlh2 overexpression plasmid group and pCAG-puro group. TdT (terminal deoxynucleotidyl transferase)-mediated dUDP nick-end labelling assay was carried out to detect the oocyte apoptosis; immunocytochemical staining and quantitative real time-polymerase chain reaction detected the expression of c-kit and Forkhead box O3a (Foxo3a); Western blot was performed to detect the expression of Sohlh2, C-kit, saerine/threonine kinases (Akt1) and Foxo3a. The results showed that Sohlh2 inhibited oocyte apoptosis and upregulated c-kit expression; Sohlh2 decreased the endonuclear Foxo3a via the upregulation of phosphorylated Akt1 (P-Akt1) and phosphorylated Foxo3a (P-Foxo3a) but not total Akt1 (T-Akt1) or total Foxo3a (T-Foxo3a); Sohlh2 increased P-Akt1 but not T-Akt1; the PI3K (phosphotidylinsitol-3-kinase) inhibitor LY294002 ameliorated the role of Sohlh2 on phosphorylation of Akt1 and Foxo3a. Sohlh2 may inhibit oocyte apoptosis via c-kit/PI3K/Akt/Foxo3a signalling pathway." @default.
• W2023021110 created "2016-06-24" @default.
• W2023021110 creator A5013115993 @default.
• W2023021110 creator A5013654875 @default.
• W2023021110 creator A5032489631 @default.
• W2023021110 creator A5054228072 @default.
• W2023021110 creator A5088821301 @default.
• W2023021110 creator A5090850568 @default.
• W2023021110 date "2015-05-01" @default.
• W2023021110 modified "2023-09-24" @default.
• W2023021110 title "Sohlh2 inhibits the apoptosis of mouse primordial follicle oocytes via C-kit/PI3K/Akt/Foxo3a signalling pathway" @default.
• W2023021110 cites W1508186720 @default.
• W2023021110 cites W1529396499 @default.
• W2023021110 cites W1967228157 @default.
• W2023021110 cites W1970230989 @default.
• W2023021110 cites W1980440773 @default.
• W2023021110 cites W1997867310 @default.
• W2023021110 cites W2007271805 @default.
• W2023021110 cites W2017927950 @default.
• W2023021110 cites W2020632804 @default.
• W2023021110 cites W2028511423 @default.
• W2023021110 cites W2029218543 @default.
• W2023021110 cites W2037341437 @default.
• W2023021110 cites W2038121812 @default.
• W2023021110 cites W2038988941 @default.
• W2023021110 cites W2098778888 @default.
• W2023021110 cites W2099361307 @default.
• W2023021110 cites W2107141257 @default.
• W2023021110 cites W2110274446 @default.
• W2023021110 cites W2125564527 @default.
• W2023021110 cites W2146120209 @default.
• W2023021110 cites W2152237832 @default.
• W2023021110 cites W2171773992 @default.
• W2023021110 doi "https://doi.org/10.1016/j.rbmo.2015.01.015" @default.
• W2023021110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25773528" @default.
• W2023021110 hasPublicationYear "2015" @default.
• W2023021110 type Work @default.
• W2023021110 sameAs 2023021110 @default.
• W2023021110 citedByCount "13" @default.
• W2023021110 countsByYear W20230211102016 @default.
• W2023021110 countsByYear W20230211102017 @default.
• W2023021110 countsByYear W20230211102018 @default.
• W2023021110 countsByYear W20230211102019 @default.
• W2023021110 countsByYear W20230211102020 @default.
• W2023021110 countsByYear W20230211102021 @default.
• W2023021110 countsByYear W20230211102022 @default.
• W2023021110 countsByYear W20230211102023 @default.
• W2023021110 crossrefType "journal-article" @default.
• W2023021110 hasAuthorship W2023021110A5013115993 @default.
• W2023021110 hasAuthorship W2023021110A5013654875 @default.
• W2023021110 hasAuthorship W2023021110A5032489631 @default.
• W2023021110 hasAuthorship W2023021110A5054228072 @default.
• W2023021110 hasAuthorship W2023021110A5088821301 @default.
• W2023021110 hasAuthorship W2023021110A5090850568 @default.
• W2023021110 hasConcept C104317684 @default.
• W2023021110 hasConcept C11960822 @default.
• W2023021110 hasConcept C127561419 @default.
• W2023021110 hasConcept C153911025 @default.
• W2023021110 hasConcept C154137905 @default.
• W2023021110 hasConcept C184235292 @default.
• W2023021110 hasConcept C185592680 @default.
• W2023021110 hasConcept C190283241 @default.
• W2023021110 hasConcept C196843134 @default.
• W2023021110 hasConcept C2776690073 @default.
• W2023021110 hasConcept C55493867 @default.
• W2023021110 hasConcept C62478195 @default.
• W2023021110 hasConcept C75217442 @default.
• W2023021110 hasConcept C86554907 @default.
• W2023021110 hasConcept C86803240 @default.
• W2023021110 hasConcept C95444343 @default.
• W2023021110 hasConceptScore W2023021110C104317684 @default.
• W2023021110 hasConceptScore W2023021110C11960822 @default.
• W2023021110 hasConceptScore W2023021110C127561419 @default.
• W2023021110 hasConceptScore W2023021110C153911025 @default.
• W2023021110 hasConceptScore W2023021110C154137905 @default.
• W2023021110 hasConceptScore W2023021110C184235292 @default.
• W2023021110 hasConceptScore W2023021110C185592680 @default.
• W2023021110 hasConceptScore W2023021110C190283241 @default.
• W2023021110 hasConceptScore W2023021110C196843134 @default.
• W2023021110 hasConceptScore W2023021110C2776690073 @default.
• W2023021110 hasConceptScore W2023021110C55493867 @default.
• W2023021110 hasConceptScore W2023021110C62478195 @default.
• W2023021110 hasConceptScore W2023021110C75217442 @default.
• W2023021110 hasConceptScore W2023021110C86554907 @default.
• W2023021110 hasConceptScore W2023021110C86803240 @default.
• W2023021110 hasConceptScore W2023021110C95444343 @default.
• W2023021110 hasFunder F4320321001 @default.
• W2023021110 hasFunder F4320324174 @default.
• W2023021110 hasIssue "5" @default.
• W2023021110 hasLocation W20230211101 @default.
• W2023021110 hasLocation W20230211102 @default.
• W2023021110 hasOpenAccess W2023021110 @default.
• W2023021110 hasPrimaryLocation W20230211101 @default.
• W2023021110 hasRelatedWork W1556314914 @default.
• W2023021110 hasRelatedWork W2048246423 @default.
• W2023021110 hasRelatedWork W2058936998 @default.
• W2023021110 hasRelatedWork W2111336104 @default.
• W2023021110 hasRelatedWork W2133248955 @default.

• next