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- W2023023930 abstract "Metabolic and functional activity of peripheral blood leukocytes were studied in two patients with familial lipochrome histiocytosis. Impaired respiration, hexose monophosphate shunt activity and nitroblue tetrazolium dye reduction following phagocytosis of latex particles were noted in patients' cells when compared with those in normal control subjects and unaffected family members. Staphylocidal capacity of blood leukocytes was similarly deficient. No carrier state was defined in the mother of these sisters. The observed deficiencies are identical to abnormalities described in male and female patients with chronic granulomatous disease. In contrast, however, the sisters herein described have consistently lacked the granulomatous response to inflammation which clinically characterizes chronic granulomatous disease. Possible pathogenetic differences are discussed." @default.
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- W2023023930 date "1970-09-01" @default.
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- W2023023930 title "Defective bactericidal activity of peripheral blood leukocytes in lipochrome histiocytosis" @default.
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- W2023023930 doi "https://doi.org/10.1016/s0002-9343(70)80023-7" @default.
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