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• W2023037135 abstract "A common assumption about protein sequences in beta-strands is that they have alternating patterns of polar and non-polar residues. It is thought that such patterns reflect the interior/exterior geometry of amino acid residue side-chains on a beta-sheet. Here we study the prevalence of simple hydrophobicity patterns in parallel and antiparallel beta-sheets in proteins of known structure and in the sequences of amyloidogenic proteins. The occurrence of 32 possible pentapeptide binary patterns (polar (P)/non-polar (N)) is computed in 1911 non-homologous protein structures. Despite their tendency to aggregate in experimentally designed proteins, the purely alternating hydrophobic/polar patterns (PNPNP and NPNPN) are most frequent in beta-sheets, typically occurring in antiparallel strands. The overall distribution of the pentapeptide binary patterns is significantly different in strands within parallel and antiparallel sheets. In both types of sheets, complementary patterns (where the hydrophobic and polar residues pair with one another) associate preferentially. We do not find alternating patterns to be common in amyloidogenic proteins or in short fragments involved directly in amyloid formation. However, we do note some similarities between patterns present in amyloidogenic sequences and those in parallel strands." @default.
• W2023037135 created "2016-06-24" @default.
• W2023037135 creator A5071783473 @default.
• W2023037135 creator A5077828042 @default.
• W2023037135 date "2002-10-01" @default.
• W2023037135 modified "2023-10-13" @default.
• W2023037135 title "On the Significance of Alternating Patterns of Polar and Non-polar Residues in Beta-strands" @default.
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• W2023037135 doi "https://doi.org/10.1016/s0022-2836(02)00973-7" @default.
• W2023037135 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12381301" @default.
• W2023037135 hasPublicationYear "2002" @default.
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