FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023045501> ?p ?o ?g. }

• W2023045501 endingPage "693" @default.
• W2023045501 startingPage "683" @default.
• W2023045501 abstract "The mitotic kinase Aurora B is concentrated at the anaphase central spindle by the kinesin MKlp2 during mitotic exit and cytokinesis. This pool of Aurora B phosphorylates substrates including the kinesin KIF4A to regulate central spindle length. In this paper, we identify a counteracting system in which PP2A-B56γ and -ε, but not PP2A-B56α, -β, and -δ, are maintained at the central spindle by KIF4A. Biochemical assays show that PP2A-B56γ can dephosphorylate the T799 Aurora B site on KIF4A and thereby counteract the Aurora B- and microtubule-stimulated ATPase activity of KIF4A. In agreement with these observations, combined silencing of PP2A-B56γ and -ε resulted in increased phosphorylation of KIF4A T799 and decreased central spindle growth in anaphase B. Furthermore, reduced turnover of regulatory phosphorylation on another Aurora B substrate MKlp1 was observed, suggesting that PP2A-B56γ and -ε play a general role opposing Aurora B at the central spindle. KIF4A and PP2A-B56γ and -ε therefore create a spatially restricted negative feedback loop counteracting Aurora B in anaphase." @default.
• W2023045501 created "2016-06-24" @default.
• W2023045501 creator A5025418838 @default.
• W2023045501 creator A5084163074 @default.
• W2023045501 creator A5085801984 @default.
• W2023045501 date "2014-12-15" @default.
• W2023045501 modified "2023-10-05" @default.
• W2023045501 title "KIF4A and PP2A–B56 form a spatially restricted feedback loop opposing Aurora B at the anaphase central spindle" @default.
• W2023045501 cites W124586463 @default.
• W2023045501 cites W1966571922 @default.
• W2023045501 cites W1969412956 @default.
• W2023045501 cites W1973519323 @default.
• W2023045501 cites W1974667981 @default.
• W2023045501 cites W1977119499 @default.
• W2023045501 cites W1985053762 @default.
• W2023045501 cites W1992887353 @default.
• W2023045501 cites W1994992878 @default.
• W2023045501 cites W1999077006 @default.
• W2023045501 cites W2000055300 @default.
• W2023045501 cites W2002367145 @default.
• W2023045501 cites W2006989477 @default.
• W2023045501 cites W2011907448 @default.
• W2023045501 cites W2016775639 @default.
• W2023045501 cites W2017600542 @default.
• W2023045501 cites W2018596631 @default.
• W2023045501 cites W2024543972 @default.
• W2023045501 cites W2027540736 @default.
• W2023045501 cites W2027964838 @default.
• W2023045501 cites W2028406725 @default.
• W2023045501 cites W2033364305 @default.
• W2023045501 cites W2041335806 @default.
• W2023045501 cites W2052271265 @default.
• W2023045501 cites W2062399016 @default.
• W2023045501 cites W2069643337 @default.
• W2023045501 cites W2070326039 @default.
• W2023045501 cites W2073153492 @default.
• W2023045501 cites W2073754955 @default.
• W2023045501 cites W2088266134 @default.
• W2023045501 cites W2088309079 @default.
• W2023045501 cites W2093061813 @default.
• W2023045501 cites W2098373061 @default.
• W2023045501 cites W2098759786 @default.
• W2023045501 cites W2112721174 @default.
• W2023045501 cites W2125247503 @default.
• W2023045501 cites W2140557275 @default.
• W2023045501 cites W2150541721 @default.
• W2023045501 cites W2152551552 @default.
• W2023045501 cites W2158113590 @default.
• W2023045501 cites W2160087268 @default.
• W2023045501 cites W2161101708 @default.
• W2023045501 cites W2162814430 @default.
• W2023045501 cites W2165691575 @default.
• W2023045501 cites W2165909436 @default.
• W2023045501 cites W2168881161 @default.
• W2023045501 cites W25499092 @default.
• W2023045501 doi "https://doi.org/10.1083/jcb.201409129" @default.
• W2023045501 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4274259" @default.
• W2023045501 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25512391" @default.
• W2023045501 hasPublicationYear "2014" @default.
• W2023045501 type Work @default.
• W2023045501 sameAs 2023045501 @default.
• W2023045501 citedByCount "69" @default.
• W2023045501 countsByYear W20230455012014 @default.
• W2023045501 countsByYear W20230455012015 @default.
• W2023045501 countsByYear W20230455012016 @default.
• W2023045501 countsByYear W20230455012017 @default.
• W2023045501 countsByYear W20230455012018 @default.
• W2023045501 countsByYear W20230455012019 @default.
• W2023045501 countsByYear W20230455012020 @default.
• W2023045501 countsByYear W20230455012021 @default.
• W2023045501 countsByYear W20230455012022 @default.
• W2023045501 countsByYear W20230455012023 @default.
• W2023045501 crossrefType "journal-article" @default.
• W2023045501 hasAuthorship W2023045501A5025418838 @default.
• W2023045501 hasAuthorship W2023045501A5084163074 @default.
• W2023045501 hasAuthorship W2023045501A5085801984 @default.
• W2023045501 hasBestOaLocation W20230455011 @default.
• W2023045501 hasConcept C11960822 @default.
• W2023045501 hasConcept C141937037 @default.
• W2023045501 hasConcept C1491633281 @default.
• W2023045501 hasConcept C178666793 @default.
• W2023045501 hasConcept C20418707 @default.
• W2023045501 hasConcept C29537977 @default.
• W2023045501 hasConcept C389152 @default.
• W2023045501 hasConcept C47432576 @default.
• W2023045501 hasConcept C53420372 @default.
• W2023045501 hasConcept C55493867 @default.
• W2023045501 hasConcept C59006786 @default.
• W2023045501 hasConcept C85813293 @default.
• W2023045501 hasConcept C86803240 @default.
• W2023045501 hasConcept C93304396 @default.
• W2023045501 hasConcept C95444343 @default.
• W2023045501 hasConceptScore W2023045501C11960822 @default.
• W2023045501 hasConceptScore W2023045501C141937037 @default.
• W2023045501 hasConceptScore W2023045501C1491633281 @default.
• W2023045501 hasConceptScore W2023045501C178666793 @default.
• W2023045501 hasConceptScore W2023045501C20418707 @default.
• W2023045501 hasConceptScore W2023045501C29537977 @default.

• next