FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023049459> ?p ?o ?g. }

• W2023049459 endingPage "2060" @default.
• W2023049459 startingPage "2052" @default.
• W2023049459 abstract "Latent autoimmune diabetes in adults (LADA) is a slowly progressive form of autoimmune diabetes, with autoantibodies to islet proteins developing in older patients who have no immediate requirement for insulin therapy. Markers of its clinical course are uncharacterised. The aim of this study was to determine whether persistence of, or changes in, GAD65 autoantibodies (GADAs) in the LADA patients who participated in the United Kingdom Prospective Diabetes Study (UKPDS) were associated with disease progression or insulin requirement.GADA levels and their relative epitope reactivities to N-terminal, middle and C-terminal regions of human GAD65 were determined in 242 UKPDS patients who were GADA-positive at diagnosis; samples taken after 0.5, 3 and 6 years of follow-up were tested using a radiobinding assay. Comparisons were made of GADA status with clinical details and disease progression assessed by the requirement for intensified glucose-lowering therapy.GADA levels fluctuated between 0.5 and 6 years but persisted in 225 of 242 patients. No association of GADA levels with disease progression or insulin requirement was observed. Antibody reactivity was directed to C-terminal and middle epitopes of GAD65 in >70% patients, and the N-terminal in <9%. There were no changes in epitope reactivity pattern over the 6 year follow-up period, nor any association between epitope reactivity and insulin requirement.GADAs persist for 6 years after diagnosis of LADA, but levels and reactivity to different GAD65 epitopes are not associated with disease progression." @default.
• W2023049459 created "2016-06-24" @default.
• W2023049459 creator A5020477659 @default.
• W2023049459 creator A5024285565 @default.
• W2023049459 creator A5026837875 @default.
• W2023049459 creator A5026899829 @default.
• W2023049459 creator A5045884090 @default.
• W2023049459 creator A5049740900 @default.
• W2023049459 creator A5053017552 @default.
• W2023049459 creator A5058744766 @default.
• W2023049459 creator A5059522259 @default.
• W2023049459 creator A5065673711 @default.
• W2023049459 creator A5068947479 @default.
• W2023049459 creator A5073399902 @default.
• W2023049459 date "2007-07-27" @default.
• W2023049459 modified "2023-10-17" @default.
• W2023049459 title "GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77" @default.
• W2023049459 cites W1970621977 @default.
• W2023049459 cites W1975588287 @default.
• W2023049459 cites W1993279402 @default.
• W2023049459 cites W1996226156 @default.
• W2023049459 cites W2005843003 @default.
• W2023049459 cites W2006439339 @default.
• W2023049459 cites W2006591202 @default.
• W2023049459 cites W2009802964 @default.
• W2023049459 cites W2026956353 @default.
• W2023049459 cites W2042504872 @default.
• W2023049459 cites W2044234363 @default.
• W2023049459 cites W2048365639 @default.
• W2023049459 cites W2050846946 @default.
• W2023049459 cites W2054981053 @default.
• W2023049459 cites W2058861592 @default.
• W2023049459 cites W2066898102 @default.
• W2023049459 cites W2067590245 @default.
• W2023049459 cites W2090432138 @default.
• W2023049459 cites W2093206869 @default.
• W2023049459 cites W2099852272 @default.
• W2023049459 cites W2114047926 @default.
• W2023049459 cites W2119441665 @default.
• W2023049459 cites W2121271546 @default.
• W2023049459 cites W2132749952 @default.
• W2023049459 cites W2134293572 @default.
• W2023049459 cites W2137638424 @default.
• W2023049459 cites W2152161585 @default.
• W2023049459 cites W2154857534 @default.
• W2023049459 cites W2158176433 @default.
• W2023049459 cites W2160234571 @default.
• W2023049459 cites W2164825421 @default.
• W2023049459 cites W2302447233 @default.
• W2023049459 cites W2337454357 @default.
• W2023049459 cites W2607031541 @default.
• W2023049459 cites W2944448728 @default.
• W2023049459 cites W4213337898 @default.
• W2023049459 cites W4238251256 @default.
• W2023049459 cites W4255885452 @default.
• W2023049459 cites W4290253331 @default.
• W2023049459 doi "https://doi.org/10.1007/s00125-007-0745-6" @default.
• W2023049459 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17657474" @default.
• W2023049459 hasPublicationYear "2007" @default.
• W2023049459 type Work @default.
• W2023049459 sameAs 2023049459 @default.
• W2023049459 citedByCount "53" @default.
• W2023049459 countsByYear W20230494592012 @default.
• W2023049459 countsByYear W20230494592013 @default.
• W2023049459 countsByYear W20230494592014 @default.
• W2023049459 countsByYear W20230494592015 @default.
• W2023049459 countsByYear W20230494592016 @default.
• W2023049459 countsByYear W20230494592017 @default.
• W2023049459 countsByYear W20230494592018 @default.
• W2023049459 countsByYear W20230494592019 @default.
• W2023049459 countsByYear W20230494592020 @default.
• W2023049459 countsByYear W20230494592021 @default.
• W2023049459 countsByYear W20230494592022 @default.
• W2023049459 countsByYear W20230494592023 @default.
• W2023049459 crossrefType "journal-article" @default.
• W2023049459 hasAuthorship W2023049459A5020477659 @default.
• W2023049459 hasAuthorship W2023049459A5024285565 @default.
• W2023049459 hasAuthorship W2023049459A5026837875 @default.
• W2023049459 hasAuthorship W2023049459A5026899829 @default.
• W2023049459 hasAuthorship W2023049459A5045884090 @default.
• W2023049459 hasAuthorship W2023049459A5049740900 @default.
• W2023049459 hasAuthorship W2023049459A5053017552 @default.
• W2023049459 hasAuthorship W2023049459A5058744766 @default.
• W2023049459 hasAuthorship W2023049459A5059522259 @default.
• W2023049459 hasAuthorship W2023049459A5065673711 @default.
• W2023049459 hasAuthorship W2023049459A5068947479 @default.
• W2023049459 hasAuthorship W2023049459A5073399902 @default.
• W2023049459 hasBestOaLocation W20230494591 @default.
• W2023049459 hasConcept C126322002 @default.
• W2023049459 hasConcept C134018914 @default.
• W2023049459 hasConcept C159654299 @default.
• W2023049459 hasConcept C163764329 @default.
• W2023049459 hasConcept C195616568 @default.
• W2023049459 hasConcept C203014093 @default.
• W2023049459 hasConcept C2779075594 @default.
• W2023049459 hasConcept C2779134260 @default.
• W2023049459 hasConcept C2781232474 @default.
• W2023049459 hasConcept C555293320 @default.

• next