FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023065741> ?p ?o ?g. }

• W2023065741 endingPage "10812" @default.
• W2023065741 startingPage "10807" @default.
• W2023065741 abstract "Understanding brain disorders, the neural processes implicated in cognitive functions and their alterations in neurodegenerative pathologies, or testing new therapies for these diseases would benefit greatly from combined use of an increasing number of rodent models and neuroimaging methods specifically adapted to the rodent brain. Besides magnetic resonance (MR) imaging and functional MR, positron-emission tomography (PET) remains a unique methodology to study in vivo brain processes. However, current high spatial-resolution tomographs suffer from several technical limitations such as high cost, low sensitivity, and the need of restraining the animal during image acquisition. We have developed a beta(+)-sensitive high temporal-resolution system that overcomes these problems and allows the in vivo quantification of cerebral biochemical processes in rodents. This beta-MICROPROBE is an in situ technique involving the insertion of a fine probe into brain tissue in a way very similar to that used for microdialysis and cell electrode recordings. In this respect, it provides information on molecular interactions and pathways, which is complementary to that produced by these technologies as well as other modalities such as MR or fluorescence imaging. This study describes two experiments that provide a proof of concept to substantiate the potential of this technique and demonstrate the feasibility of quantifying brain activation or metabolic depression in individual living rats with 2-[(18)F]fluoro-2-deoxy-d-glucose and standard compartmental modeling techniques. Furthermore, it was possible to identify correctly the origin of variations in glucose consumption at the hexokinase level, which demonstrate the strength of the method and its adequacy for in vivo quantitative metabolic studies in small animals." @default.
• W2023065741 created "2016-06-24" @default.
• W2023065741 creator A5001112573 @default.
• W2023065741 creator A5006499597 @default.
• W2023065741 creator A5010030582 @default.
• W2023065741 creator A5016740898 @default.
• W2023065741 creator A5051377002 @default.
• W2023065741 creator A5056029125 @default.
• W2023065741 creator A5061932606 @default.
• W2023065741 creator A5065611243 @default.
• W2023065741 creator A5073574648 @default.
• W2023065741 creator A5078998293 @default.
• W2023065741 creator A5073136598 @default.
• W2023065741 date "2002-07-22" @default.
• W2023065741 modified "2023-10-15" @default.
• W2023065741 title "In vivo quantification of localized neuronal activation and inhibition in the rat brain using a dedicated high temporal-resolution +-sensitive microprobe" @default.
• W2023065741 cites W1530150042 @default.
• W2023065741 cites W1680536342 @default.
• W2023065741 cites W171972150 @default.
• W2023065741 cites W1885512122 @default.
• W2023065741 cites W1925393549 @default.
• W2023065741 cites W1951442280 @default.
• W2023065741 cites W1976395982 @default.
• W2023065741 cites W1978415275 @default.
• W2023065741 cites W1980611143 @default.
• W2023065741 cites W1991970216 @default.
• W2023065741 cites W2005606566 @default.
• W2023065741 cites W2011025664 @default.
• W2023065741 cites W2020213329 @default.
• W2023065741 cites W2020950334 @default.
• W2023065741 cites W2035360655 @default.
• W2023065741 cites W2045335742 @default.
• W2023065741 cites W2057605474 @default.
• W2023065741 cites W2060967710 @default.
• W2023065741 cites W2073373103 @default.
• W2023065741 cites W2077298522 @default.
• W2023065741 cites W2077321554 @default.
• W2023065741 cites W2080452677 @default.
• W2023065741 cites W2085285717 @default.
• W2023065741 cites W2090203522 @default.
• W2023065741 cites W2090306035 @default.
• W2023065741 cites W2092247954 @default.
• W2023065741 cites W2096268384 @default.
• W2023065741 cites W2118010779 @default.
• W2023065741 cites W2147486876 @default.
• W2023065741 cites W2164432663 @default.
• W2023065741 cites W3202857298 @default.
• W2023065741 doi "https://doi.org/10.1073/pnas.162368899" @default.
• W2023065741 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/125052" @default.
• W2023065741 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12136134" @default.
• W2023065741 hasPublicationYear "2002" @default.
• W2023065741 type Work @default.
• W2023065741 sameAs 2023065741 @default.
• W2023065741 citedByCount "32" @default.
• W2023065741 countsByYear W20230657412012 @default.
• W2023065741 countsByYear W20230657412013 @default.
• W2023065741 countsByYear W20230657412014 @default.
• W2023065741 countsByYear W20230657412015 @default.
• W2023065741 countsByYear W20230657412017 @default.
• W2023065741 crossrefType "journal-article" @default.
• W2023065741 hasAuthorship W2023065741A5001112573 @default.
• W2023065741 hasAuthorship W2023065741A5006499597 @default.
• W2023065741 hasAuthorship W2023065741A5010030582 @default.
• W2023065741 hasAuthorship W2023065741A5016740898 @default.
• W2023065741 hasAuthorship W2023065741A5051377002 @default.
• W2023065741 hasAuthorship W2023065741A5056029125 @default.
• W2023065741 hasAuthorship W2023065741A5061932606 @default.
• W2023065741 hasAuthorship W2023065741A5065611243 @default.
• W2023065741 hasAuthorship W2023065741A5073136598 @default.
• W2023065741 hasAuthorship W2023065741A5073574648 @default.
• W2023065741 hasAuthorship W2023065741A5078998293 @default.
• W2023065741 hasBestOaLocation W20230657412 @default.
• W2023065741 hasConcept C119666444 @default.
• W2023065741 hasConcept C121332964 @default.
• W2023065741 hasConcept C125206250 @default.
• W2023065741 hasConcept C126838900 @default.
• W2023065741 hasConcept C136229726 @default.
• W2023065741 hasConcept C143409427 @default.
• W2023065741 hasConcept C150903083 @default.
• W2023065741 hasConcept C169760540 @default.
• W2023065741 hasConcept C185592680 @default.
• W2023065741 hasConcept C199289684 @default.
• W2023065741 hasConcept C207001950 @default.
• W2023065741 hasConcept C2775842073 @default.
• W2023065741 hasConcept C2777670902 @default.
• W2023065741 hasConcept C29331040 @default.
• W2023065741 hasConcept C41008148 @default.
• W2023065741 hasConcept C58693492 @default.
• W2023065741 hasConcept C62520636 @default.
• W2023065741 hasConcept C71924100 @default.
• W2023065741 hasConcept C86803240 @default.
• W2023065741 hasConceptScore W2023065741C119666444 @default.
• W2023065741 hasConceptScore W2023065741C121332964 @default.
• W2023065741 hasConceptScore W2023065741C125206250 @default.
• W2023065741 hasConceptScore W2023065741C126838900 @default.
• W2023065741 hasConceptScore W2023065741C136229726 @default.
• W2023065741 hasConceptScore W2023065741C143409427 @default.
• W2023065741 hasConceptScore W2023065741C150903083 @default.

• next