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- W2023067433 endingPage "941" @default.
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- W2023067433 abstract "Highly crosslinked hydrogel spheres were fabricated using UV photopolymerization of poly(ethylene glycol) diacrylate (PEG-DA) and pentaerythritol triacrylate (PETA) with 2,2′-dimethoxy-2-phenyl-acetophenone (DMPA) as the photoinitiator. Spheres were fabricated both with and without one of three comonomers: acrylic acid, acrylamide or allylamine. Photopolymerization rates and polymer morphology were determined using attenuated total reflectance/Fourier transform infrared spectroscopy and electron microscopy, respectively. These gels were further characterized for volume change, equilibrium water content, diffusivity of the expanding gel, molecular weight between crosslinks and polymer mesh size. Hydrogels with comonomers generally demonstrated an increase in equilibrium water content, average molecular weight between crosslinks and mesh size. Bovine serum albumin was incorporated into the hydrogel to simulate delivery of a model protein drug. The protein diffusion coefficients, based a Fickian release model, were calculated to be between 10−10 and 10−12 cm2/s with slight variance due to PETA concentration and the type of comonomer used." @default.
- W2023067433 created "2016-06-24" @default.
- W2023067433 creator A5034856587 @default.
- W2023067433 creator A5065127154 @default.
- W2023067433 creator A5081379168 @default.
- W2023067433 date "2001-05-01" @default.
- W2023067433 modified "2023-09-30" @default.
- W2023067433 title "Release of protein from highly cross-linked hydrogels of poly(ethylene glycol) diacrylate fabricated by UV polymerization" @default.
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- W2023067433 doi "https://doi.org/10.1016/s0142-9612(00)00258-1" @default.
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