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- W2023072009 startingPage "2340" @default.
- W2023072009 abstract "Despite their rarity, diseases of premature aging, or progeroid syndromes, have provided important insights into basic mechanisms that may underlie cancer and normal aging. In this review, we highlight these recent developments in Hutchinson-Gilford progeria syndrome (HGPS), Werner syndrome, Bloom syndrome, Cockayne syndrome, trichothiodystrophy, ataxia-telangiectasia, Rothmund-Thomson syndrome, and xeroderma pigmentosum. Though they are caused by different mutations in various genes and often result in quite disparate phenotypes, deciphering the molecular bases of these conditions has served to highlight their underlying basic similarities. Studies of progeroid syndromes, particularly HGPS, the most dramatic form of premature aging, have contributed to our knowledge of fundamental processes of importance to skin biology, including DNA transcription, replication, and repair, genome instability, cellular senescence, and stem-cell differentiation." @default.
- W2023072009 created "2016-06-24" @default.
- W2023072009 creator A5013617649 @default.
- W2023072009 creator A5016182638 @default.
- W2023072009 creator A5034687469 @default.
- W2023072009 date "2009-10-01" @default.
- W2023072009 modified "2023-10-06" @default.
- W2023072009 title "From the Rarest to the Most Common: Insights from Progeroid Syndromes into Skin Cancer and Aging" @default.
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