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- W2023075963 abstract "Significance Saponins are plant molecules that are produced as a chemical defense against herbivores and eukaryotic pathogens. They constitute structurally diverse, bioactive compounds composed of a 30-carbon triterpene backbone adorned with multiple functional groups and sugars. Saikosaponins are abundant saponins accumulating in the Asian medicinal plant Bupleurum falcatum , but none of the enzymes involved in their biosynthesis had been characterized. We identified a cytochrome P450 involved in the oxidation of saikosaponins, thereby expanding the enzyme compendium that can generate plant saponins with an extra activity. Using this enzyme compendium, we established a synthetic biology program to reconstitute saponin biosynthesis in the yeast Saccharomyces cerevisiae and developed a cyclodextrin-based culturing strategy to sequester triterpenes from engineered yeast cells and enhance their productivity." @default.
- W2023075963 created "2016-06-24" @default.
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- W2023075963 date "2014-01-13" @default.
- W2023075963 modified "2023-10-16" @default.
- W2023075963 title "Combinatorial biosynthesis of sapogenins and saponins in <i>Saccharomyces cerevisiae</i> using a C-16α hydroxylase from <i>Bupleurum falcatum</i>" @default.
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- W2023075963 doi "https://doi.org/10.1073/pnas.1323369111" @default.
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