FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023081030> ?p ?o ?g. }

• W2023081030 endingPage "107" @default.
• W2023081030 startingPage "101" @default.
• W2023081030 abstract "Membrane vesicles (MVs) released from activated cells and blebs from apoptotic cells are increased in patients with vascular disease and in those with atherosclerotic lesions, and their contribution to inflammatory reactions has been suggested. At sites of inflammation, MVs could serve as rapidly available substrates for peroxidation, carry oxidized compounds to activate other cells, and amplify inflammation. Here, we show that MVs released from tert-butyl hydroperoxide-treated endothelial cells (ECs) and apoptotic blebs, but not MVs from Ca(2+) ionophore-treated ECs, stimulate monocyte adhesion to ECs, an important step in atherogenesis. We show that oxidized phospholipids, such as the previously identified 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine (POVPC), are responsible for biological activity in MVs and apoptotic blebs. Natural antibodies from apolipoprotein E-null mice that recognize POVPC also recognize oxidized MVs, and pretreatment of MVs with these antibodies inhibits their ability to activate ECs. Furthermore, the biological activity of oxidized MVs is inhibited by platelet-activating factor receptor antagonists, which have been shown to inhibit the action of POVPC. Taken together, we show that oxidized MVs and apoptotic blebs stimulate ECs to specifically bind monocytes, with oxidized phospholipids (POVPC) being the active principle. In addition to oxidized lipoproteins, oxidized MVs and apoptotic blebs may play an important role in chronic inflammatory diseases, such as atherosclerosis." @default.
• W2023081030 created "2016-06-24" @default.
• W2023081030 creator A5018136553 @default.
• W2023081030 creator A5021117843 @default.
• W2023081030 creator A5026327822 @default.
• W2023081030 creator A5031147915 @default.
• W2023081030 creator A5037079092 @default.
• W2023081030 creator A5051208927 @default.
• W2023081030 creator A5054347355 @default.
• W2023081030 creator A5083238939 @default.
• W2023081030 date "2002-01-01" @default.
• W2023081030 modified "2023-10-10" @default.
• W2023081030 title "Oxidized Membrane Vesicles and Blebs From Apoptotic Cells Contain Biologically Active Oxidized Phospholipids That Induce Monocyte-Endothelial Interactions" @default.
• W2023081030 cites W1549348777 @default.
• W2023081030 cites W165853039 @default.
• W2023081030 cites W182898904 @default.
• W2023081030 cites W1965056341 @default.
• W2023081030 cites W1972365386 @default.
• W2023081030 cites W1990648591 @default.
• W2023081030 cites W1999953111 @default.
• W2023081030 cites W2004104374 @default.
• W2023081030 cites W2008890523 @default.
• W2023081030 cites W2020438152 @default.
• W2023081030 cites W2030383998 @default.
• W2023081030 cites W2053561492 @default.
• W2023081030 cites W2054792986 @default.
• W2023081030 cites W2065947716 @default.
• W2023081030 cites W2066385795 @default.
• W2023081030 cites W2074619822 @default.
• W2023081030 cites W2080314410 @default.
• W2023081030 cites W2100668681 @default.
• W2023081030 cites W2101575450 @default.
• W2023081030 cites W2107667162 @default.
• W2023081030 cites W2113993611 @default.
• W2023081030 cites W2122931119 @default.
• W2023081030 cites W2132845895 @default.
• W2023081030 cites W2133308354 @default.
• W2023081030 cites W2137511741 @default.
• W2023081030 cites W2138253156 @default.
• W2023081030 cites W2145998570 @default.
• W2023081030 cites W2150545098 @default.
• W2023081030 cites W2161165626 @default.
• W2023081030 cites W2166291746 @default.
• W2023081030 cites W2184072247 @default.
• W2023081030 cites W2210054086 @default.
• W2023081030 cites W2404153495 @default.
• W2023081030 cites W2408066211 @default.
• W2023081030 cites W2409894076 @default.
• W2023081030 cites W2412109671 @default.
• W2023081030 cites W36050078 @default.
• W2023081030 doi "https://doi.org/10.1161/hq0102.101525" @default.
• W2023081030 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11788468" @default.
• W2023081030 hasPublicationYear "2002" @default.
• W2023081030 type Work @default.
• W2023081030 sameAs 2023081030 @default.
• W2023081030 citedByCount "256" @default.
• W2023081030 countsByYear W20230810302012 @default.
• W2023081030 countsByYear W20230810302013 @default.
• W2023081030 countsByYear W20230810302014 @default.
• W2023081030 countsByYear W20230810302015 @default.
• W2023081030 countsByYear W20230810302016 @default.
• W2023081030 countsByYear W20230810302017 @default.
• W2023081030 countsByYear W20230810302018 @default.
• W2023081030 countsByYear W20230810302019 @default.
• W2023081030 countsByYear W20230810302020 @default.
• W2023081030 countsByYear W20230810302021 @default.
• W2023081030 countsByYear W20230810302022 @default.
• W2023081030 countsByYear W20230810302023 @default.
• W2023081030 crossrefType "journal-article" @default.
• W2023081030 hasAuthorship W2023081030A5018136553 @default.
• W2023081030 hasAuthorship W2023081030A5021117843 @default.
• W2023081030 hasAuthorship W2023081030A5026327822 @default.
• W2023081030 hasAuthorship W2023081030A5031147915 @default.
• W2023081030 hasAuthorship W2023081030A5037079092 @default.
• W2023081030 hasAuthorship W2023081030A5051208927 @default.
• W2023081030 hasAuthorship W2023081030A5054347355 @default.
• W2023081030 hasAuthorship W2023081030A5083238939 @default.
• W2023081030 hasBestOaLocation W20230810301 @default.
• W2023081030 hasConcept C185592680 @default.
• W2023081030 hasConcept C190283241 @default.
• W2023081030 hasConcept C203014093 @default.
• W2023081030 hasConcept C2776833585 @default.
• W2023081030 hasConcept C2776914184 @default.
• W2023081030 hasConcept C2781184567 @default.
• W2023081030 hasConcept C55493867 @default.
• W2023081030 hasConcept C86803240 @default.
• W2023081030 hasConcept C95444343 @default.
• W2023081030 hasConceptScore W2023081030C185592680 @default.
• W2023081030 hasConceptScore W2023081030C190283241 @default.
• W2023081030 hasConceptScore W2023081030C203014093 @default.
• W2023081030 hasConceptScore W2023081030C2776833585 @default.
• W2023081030 hasConceptScore W2023081030C2776914184 @default.
• W2023081030 hasConceptScore W2023081030C2781184567 @default.
• W2023081030 hasConceptScore W2023081030C55493867 @default.
• W2023081030 hasConceptScore W2023081030C86803240 @default.
• W2023081030 hasConceptScore W2023081030C95444343 @default.
• W2023081030 hasIssue "1" @default.
• W2023081030 hasLocation W20230810301 @default.

• next