FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023081942> ?p ?o ?g. }

• W2023081942 endingPage "122" @default.
• W2023081942 startingPage "107" @default.
• W2023081942 abstract "It has long been known that polyamines play an essential role in the proliferation of mammalian cells, and the polyamine biosynthetic pathway may provide an important target for the development of agents that inhibit carcinogenesis and tumor growth. The rate-limiting enzymes of the polyamine pathway, ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (AdoMetDC), are highly regulated in the cell, and much of this regulation occurs at the level of translation. Although the 5′ leader sequences of ODC and AdoMetDC are both highly structured and contain small internal open reading frames (ORFs), the regulation of their translation appears to be quite different. The translational regulation of ODC is more dependent on secondary structure, and therefore responds to the intracellular availability of active eIF-4E, the cap-binding subunit of the eIF-4F complex, which mediates translation initiation. Cell-specific translation of AdoMetDC appears to be regulated exclusively through the internal ORF, which causes ribosome stalling that is independent of eIF-4E levels and decreases the efficiency with which the downstream ORF encoding AdoMetDC protein is translated. The translation of both ODC and AdoMetDC is negatively regulated by intracellular changes in the polyamines spermidine and spermine. Thus, when polyamine levels are low, the synthesis of both ODC and AdoMetDC is increased, and an increase in polyamine content causes a corresponding decrease in protein synthesis. However, an increase in active eIF-4E may allow for the synthesis of ODC even in the presence of polyamine levels that repress ODC translation in cells with lower levels of the initiation factor. In contrast, the amino acid sequence that is encoded by the upstream ORF is critical for polyamine regulation of AdoMetDC synthesis, and polyamines may affect synthesis by interaction with the putative peptide, MAGDIS." @default.
• W2023081942 created "2016-06-24" @default.
• W2023081942 creator A5004925869 @default.
• W2023081942 creator A5040141654 @default.
• W2023081942 date "1999-01-01" @default.
• W2023081942 modified "2023-09-27" @default.
• W2023081942 title "Translational regulation of ornithine decarboxylase and other enzymes of the polyamine pathway" @default.
• W2023081942 cites W138761429 @default.
• W2023081942 cites W1492413568 @default.
• W2023081942 cites W1495632188 @default.
• W2023081942 cites W1502750012 @default.
• W2023081942 cites W1505438501 @default.
• W2023081942 cites W1507623075 @default.
• W2023081942 cites W1525853704 @default.
• W2023081942 cites W1528915146 @default.
• W2023081942 cites W1531330835 @default.
• W2023081942 cites W1546570611 @default.
• W2023081942 cites W1551420438 @default.
• W2023081942 cites W1556342932 @default.
• W2023081942 cites W1559823782 @default.
• W2023081942 cites W1559964797 @default.
• W2023081942 cites W1564741789 @default.
• W2023081942 cites W1567178433 @default.
• W2023081942 cites W1573512808 @default.
• W2023081942 cites W1574765020 @default.
• W2023081942 cites W1579360091 @default.
• W2023081942 cites W1581341594 @default.
• W2023081942 cites W1586269508 @default.
• W2023081942 cites W1588345440 @default.
• W2023081942 cites W1601723642 @default.
• W2023081942 cites W1602545070 @default.
• W2023081942 cites W1604461344 @default.
• W2023081942 cites W1607579928 @default.
• W2023081942 cites W1616429637 @default.
• W2023081942 cites W1695463822 @default.
• W2023081942 cites W1783564941 @default.
• W2023081942 cites W1801096283 @default.
• W2023081942 cites W1866293086 @default.
• W2023081942 cites W1874612019 @default.
• W2023081942 cites W1886970805 @default.
• W2023081942 cites W1912098244 @default.
• W2023081942 cites W1963849454 @default.
• W2023081942 cites W1964819733 @default.
• W2023081942 cites W1965894414 @default.
• W2023081942 cites W1965924635 @default.
• W2023081942 cites W1966275499 @default.
• W2023081942 cites W1970013273 @default.
• W2023081942 cites W1970497539 @default.
• W2023081942 cites W1971640607 @default.
• W2023081942 cites W1976365049 @default.
• W2023081942 cites W1979190173 @default.
• W2023081942 cites W1981001162 @default.
• W2023081942 cites W1982172428 @default.
• W2023081942 cites W1984672754 @default.
• W2023081942 cites W1989186349 @default.
• W2023081942 cites W1992900034 @default.
• W2023081942 cites W1997806157 @default.
• W2023081942 cites W2002664542 @default.
• W2023081942 cites W2004800814 @default.
• W2023081942 cites W2019565345 @default.
• W2023081942 cites W2020998971 @default.
• W2023081942 cites W2023713880 @default.
• W2023081942 cites W2033468679 @default.
• W2023081942 cites W2042397686 @default.
• W2023081942 cites W2044177020 @default.
• W2023081942 cites W2053504500 @default.
• W2023081942 cites W2059433877 @default.
• W2023081942 cites W2060945692 @default.
• W2023081942 cites W2064011163 @default.
• W2023081942 cites W2068504618 @default.
• W2023081942 cites W2068882880 @default.
• W2023081942 cites W2069652470 @default.
• W2023081942 cites W2070436419 @default.
• W2023081942 cites W2071306117 @default.
• W2023081942 cites W2074997738 @default.
• W2023081942 cites W2089317321 @default.
• W2023081942 cites W2099136664 @default.
• W2023081942 cites W2100025889 @default.
• W2023081942 cites W2102278661 @default.
• W2023081942 cites W2106631130 @default.
• W2023081942 cites W2107163098 @default.
• W2023081942 cites W2114758061 @default.
• W2023081942 cites W2116879291 @default.
• W2023081942 cites W2135294940 @default.
• W2023081942 cites W2138761043 @default.
• W2023081942 cites W2140028217 @default.
• W2023081942 cites W2141142935 @default.
• W2023081942 cites W2165055107 @default.
• W2023081942 cites W2168847939 @default.
• W2023081942 cites W2200449809 @default.
• W2023081942 cites W2203934997 @default.
• W2023081942 cites W2205608213 @default.
• W2023081942 cites W2209075806 @default.
• W2023081942 cites W2235872018 @default.
• W2023081942 cites W2319342642 @default.
• W2023081942 cites W2322308298 @default.
• W2023081942 cites W2328711865 @default.
• W2023081942 cites W2341438571 @default.

• next