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• W2023082261 abstract "In the present investigation, the ability of two known hallucinogens, lysergic acid dimethylamide (LSD) and (−)-2,5-dimethoxy-4-methyl-amphetamine (DOM), to substitute for the ibogaine-induced discriminative stimulus (10 mg/kg IP, 60 min presession) was assessed in Fischer-344 rats. In these subjects, intermediate levels of generalization were observed to both agents (LSD, 63%; DOM, 66.4%). This intermediate generalization was completely blocked by pretreatment with the 5-HT2A antagonist pirenpirone, suggesting that the ibogaine-like effects of these agents are mediated by the 5-HT2A receptor. However, pirenpirone did not antagonize ibogaine itself, nor did it antagonize the ibogaine-like effects of harmaline and 12-hydroxyibogamine (noribogaine). To further evaluate the serotonergic properties of ibogaine, in vivo protection assays and in vitro binding assays were employed. Micromolar 5-HT2A affinity was observed with ibogaine (92.5 μM), 12-hydroxyibogamine (34.5 μM), and harmaline (42.5 μM). Despite the apparently low affinity of these agents, both ibogaine and harmaline, but not 12-hydroxyibogamine, produced significant protection from receptor alkylation by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) when given 60 min prior to this alkylating agent. The results of these studies suggest that although ibogaine may produce some of its effects via interactions with 5-HT2A receptors, these do not appear to be essential to the ibogaine-induced discriminative stimulus." @default.
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• W2023082261 date "1998-02-01" @default.
• W2023082261 modified "2023-09-28" @default.
• W2023082261 title "Behavioral and Biochemical Evidence for a Nonessential 5-HT2A Component of the Ibogaine-Induced Discriminative Stimulus" @default.
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• W2023082261 doi "https://doi.org/10.1016/s0091-3057(97)00451-6" @default.
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