FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023082289> ?p ?o ?g. }

• W2023082289 endingPage "2677" @default.
• W2023082289 startingPage "2667" @default.
• W2023082289 abstract "Abstract Inhibitory-cell killer immunoglobulin-like receptors (KIR) negatively regulate natural killer (NK) cell–mediated killing of HLA class I–expressing tumors. Lack of KIR-HLA class I interactions has been associated with potent NK-mediated antitumor efficacy and increased survival in acute myeloid leukemia (AML) patients upon haploidentical stem cell transplantation from KIR-mismatched donors. To exploit this pathway pharmacologically, we generated a fully human monoclonal antibody, 1-7F9, which cross-reacts with KIR2DL1, -2, and -3 receptors, and prevents their inhibitory signaling. The 1-7F9 monoclonal antibody augmented NK cell–mediated lysis of HLA-C–expressing tumor cells, including autologous AML blasts, but did not induce killing of normal peripheral blood mononuclear cells, suggesting a therapeutic window for preferential enhancement of NK-cell cytotoxicity against malignant target cells. Administration of 1-7F9 to KIR2DL3-transgenic mice resulted in dose-dependent rejection of HLA-Cw3–positive target cells. In an immunodeficient mouse model in which inoculation of human NK cells alone was unable to protect against lethal, autologous AML, preadministration of 1-7F9 resulted in long-term survival. These data show that 1-7F9 confers specific, stable blockade of KIR, boosting NK-mediated killing of HLA-matched AML blasts in vitro and in vivo, providing a preclinical basis for initiating phase 1 clinical trials with this candidate therapeutic antibody." @default.
• W2023082289 created "2016-06-24" @default.
• W2023082289 creator A5003282010 @default.
• W2023082289 creator A5006168813 @default.
• W2023082289 creator A5006521329 @default.
• W2023082289 creator A5008075749 @default.
• W2023082289 creator A5020843731 @default.
• W2023082289 creator A5023634131 @default.
• W2023082289 creator A5040151837 @default.
• W2023082289 creator A5045217032 @default.
• W2023082289 creator A5049192022 @default.
• W2023082289 creator A5057013667 @default.
• W2023082289 creator A5061502185 @default.
• W2023082289 creator A5070029054 @default.
• W2023082289 creator A5073433096 @default.
• W2023082289 creator A5073720570 @default.
• W2023082289 creator A5081934519 @default.
• W2023082289 creator A5082011377 @default.
• W2023082289 date "2009-09-24" @default.
• W2023082289 modified "2023-10-11" @default.
• W2023082289 title "Preclinical characterization of 1-7F9, a novel human anti–KIR receptor therapeutic antibody that augments natural killer–mediated killing of tumor cells" @default.
• W2023082289 cites W1500207187 @default.
• W2023082289 cites W1571334635 @default.
• W2023082289 cites W1969464492 @default.
• W2023082289 cites W1986353809 @default.
• W2023082289 cites W1994126734 @default.
• W2023082289 cites W1994232628 @default.
• W2023082289 cites W2003882269 @default.
• W2023082289 cites W2014643321 @default.
• W2023082289 cites W2016200146 @default.
• W2023082289 cites W2017960234 @default.
• W2023082289 cites W2025633822 @default.
• W2023082289 cites W2027182248 @default.
• W2023082289 cites W2034207391 @default.
• W2023082289 cites W2037133606 @default.
• W2023082289 cites W2038994424 @default.
• W2023082289 cites W2039638023 @default.
• W2023082289 cites W2052502668 @default.
• W2023082289 cites W2055513503 @default.
• W2023082289 cites W2062961963 @default.
• W2023082289 cites W2070551124 @default.
• W2023082289 cites W2073300038 @default.
• W2023082289 cites W2079923162 @default.
• W2023082289 cites W2080826082 @default.
• W2023082289 cites W2084896925 @default.
• W2023082289 cites W2088513299 @default.
• W2023082289 cites W2090301882 @default.
• W2023082289 cites W2093116728 @default.
• W2023082289 cites W2098130458 @default.
• W2023082289 cites W2098734667 @default.
• W2023082289 cites W2098930452 @default.
• W2023082289 cites W2100482220 @default.
• W2023082289 cites W2101283545 @default.
• W2023082289 cites W2106273338 @default.
• W2023082289 cites W2113393586 @default.
• W2023082289 cites W2119779707 @default.
• W2023082289 cites W2120549614 @default.
• W2023082289 cites W2122144067 @default.
• W2023082289 cites W2147068163 @default.
• W2023082289 cites W2161165126 @default.
• W2023082289 cites W2164296311 @default.
• W2023082289 cites W2165813814 @default.
• W2023082289 cites W2169399308 @default.
• W2023082289 cites W2171709048 @default.
• W2023082289 cites W2258225212 @default.
• W2023082289 cites W35202944 @default.
• W2023082289 doi "https://doi.org/10.1182/blood-2009-02-206532" @default.
• W2023082289 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2756126" @default.
• W2023082289 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19553639" @default.
• W2023082289 hasPublicationYear "2009" @default.
• W2023082289 type Work @default.
• W2023082289 sameAs 2023082289 @default.
• W2023082289 citedByCount "339" @default.
• W2023082289 countsByYear W20230822892012 @default.
• W2023082289 countsByYear W20230822892013 @default.
• W2023082289 countsByYear W20230822892014 @default.
• W2023082289 countsByYear W20230822892015 @default.
• W2023082289 countsByYear W20230822892016 @default.
• W2023082289 countsByYear W20230822892017 @default.
• W2023082289 countsByYear W20230822892018 @default.
• W2023082289 countsByYear W20230822892019 @default.
• W2023082289 countsByYear W20230822892020 @default.
• W2023082289 countsByYear W20230822892021 @default.
• W2023082289 countsByYear W20230822892022 @default.
• W2023082289 countsByYear W20230822892023 @default.
• W2023082289 crossrefType "journal-article" @default.
• W2023082289 hasAuthorship W2023082289A5003282010 @default.
• W2023082289 hasAuthorship W2023082289A5006168813 @default.
• W2023082289 hasAuthorship W2023082289A5006521329 @default.
• W2023082289 hasAuthorship W2023082289A5008075749 @default.
• W2023082289 hasAuthorship W2023082289A5020843731 @default.
• W2023082289 hasAuthorship W2023082289A5023634131 @default.
• W2023082289 hasAuthorship W2023082289A5040151837 @default.
• W2023082289 hasAuthorship W2023082289A5045217032 @default.
• W2023082289 hasAuthorship W2023082289A5049192022 @default.
• W2023082289 hasAuthorship W2023082289A5057013667 @default.
• W2023082289 hasAuthorship W2023082289A5061502185 @default.
• W2023082289 hasAuthorship W2023082289A5070029054 @default.

• next