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• W2023088048 endingPage "31448" @default.
• W2023088048 startingPage "31442" @default.
• W2023088048 abstract "The genes encoding the peroxisomal beta-oxidation enzymes enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase (HD) and fatty acyl-CoA oxidase (AOx) are coordinately regulated by peroxisome proliferator-activated receptor alpha (PPARalpha)/9-cis-retinoic acid receptor (RXRalpha) heterodimers that transactivate these genes in a ligand-dependent manner via upstream peroxisome proliferator response elements (PPRE). Here we demonstrate that the monomeric orphan nuclear hormone receptor, RZRalpha, modulates PPARalpha/RXRalpha-dependent transactivation in a response-element dependent manner. Electrophoretic mobility shift analysis showed that RZRalpha bound specifically as a monomer to the HD-PPRE but not the AOx-PPRE. Determinants in the HD-PPRE for binding of RZRalpha were distinct from those required for interaction with PPARalpha/RXRalpha heterodimers. In transient transfections, RZRalpha stimulated ligand-mediated transactivation by PPARalpha from an HD-PPRE luciferase reporter in the absence of exogenously added RXRalpha, but did not affect PPARalpha-dependent transactivation of an AOx-PPRE reporter gene. These data illustrate cross-talk between the RZRalpha and PPARalpha signaling pathways at the level of the HD-PPRE in the regulation of the HD gene and characterize additional factors governing the regulation of peroxisomal beta-oxidation." @default.
• W2023088048 created "2016-06-24" @default.
• W2023088048 creator A5012881642 @default.
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• W2023088048 date "1998-11-01" @default.
• W2023088048 modified "2023-09-26" @default.
• W2023088048 title "Cross-talk between Orphan Nuclear Hormone Receptor RZRα and Peroxisome Proliferator-activated Receptor α in Regulation of the Peroxisomal Hydratase-Dehydrogenase Gene" @default.
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• W2023088048 doi "https://doi.org/10.1074/jbc.273.47.31442" @default.
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