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- W2023088087 abstract "A radioimmunoassay for determining plasma concentrations of corticotrophin (A.C.T.H.) in man has been developed using synthetic human A.C.T.H. for standardisation and for radioiodination and a rabbit antiserum raised against natural human A.C.T.H. Normal basal A.C.T.H. levels in venous blood taken between 8 and 10 A.M. ranged from 12 to 55 pg. per ml. of plasma. Levels were undetectable in subjects pretreated with dexamethasone, in patients with hypopituitarism, and in a patient with Cushing's syndrome associated with an adrenal carcinoma. Increased plasma concentrations were observed after adrenalectomy and in patients with Cushing's disease and with the ectopic A.C.T.H. producing syndrome . The administration of insulin, lysine8-vasopressin, or metyrapone to normal subjects, resulted in a rise of circulating A.C.T.H. levels." @default.
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- W2023088087 date "1968-02-01" @default.
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- W2023088087 title "HOMOLOGOUS RADIOIMMUNOASSAY FOR PLASMA-LEVELS OF CORTICOTROPHIN IN MAN" @default.
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- W2023088087 doi "https://doi.org/10.1016/s0140-6736(68)90122-0" @default.
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