Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023089898> ?p ?o ?g. }
- W2023089898 endingPage "2059" @default.
- W2023089898 startingPage "2052" @default.
- W2023089898 abstract "A library of imidazoline-aminophenol ligands was synthesized on solid supports. After immobilization of chiral chloromethylimidazolines 1 and 2 onto the polystyrylsulfonyl chloride, nucleophilic substitution with (R)- or (S)-phenylethylamine (3 and 4) provided four combinations of polymer-supported imidazoline-amine ligands. Further reductive alkylation using salicylaldehydes 7-10 provided a series of imidazoline-aminophenol ligands (L9-L24). Analysis by solid-phase catalysis/circular dichroism high-throughput screening of a copper-catalyzed Henry reaction revealed that ligand L25, comprising a (S,S)-diphenylethylenediamine-derived imidazoline, (S)-phenylethylamine, and dibromophenol, was highly efficient, thus providing the adduct of nitromethane and benzaldehyde in 95 % ee. The combination of stereogenic centers was crucial in promoting the highly stereoselective reactions. The unique reaction sphere of L25 was also examined in a Friedel-Crafts alkylation of indole and nitroalkene to give the adduct in up to 83 % ee." @default.
- W2023089898 created "2016-06-24" @default.
- W2023089898 creator A5043024558 @default.
- W2023089898 creator A5090314981 @default.
- W2023089898 creator A5091855839 @default.
- W2023089898 date "2008-02-27" @default.
- W2023089898 modified "2023-10-14" @default.
- W2023089898 title "A Library of Chiral Imidazoline–Aminophenol Ligands: Discovery of an Efficient Reaction Sphere" @default.
- W2023089898 cites W1892766106 @default.
- W2023089898 cites W1964666522 @default.
- W2023089898 cites W1968056976 @default.
- W2023089898 cites W1968515145 @default.
- W2023089898 cites W1972011585 @default.
- W2023089898 cites W1972789587 @default.
- W2023089898 cites W1976165583 @default.
- W2023089898 cites W2000449378 @default.
- W2023089898 cites W2008860037 @default.
- W2023089898 cites W2024058707 @default.
- W2023089898 cites W2027320649 @default.
- W2023089898 cites W2030787135 @default.
- W2023089898 cites W2042996159 @default.
- W2023089898 cites W2051611139 @default.
- W2023089898 cites W2058373131 @default.
- W2023089898 cites W2061029888 @default.
- W2023089898 cites W2062603881 @default.
- W2023089898 cites W2063180939 @default.
- W2023089898 cites W2069340996 @default.
- W2023089898 cites W2085165495 @default.
- W2023089898 cites W2090817666 @default.
- W2023089898 cites W2093512561 @default.
- W2023089898 cites W2114775037 @default.
- W2023089898 cites W2121351614 @default.
- W2023089898 cites W2130029359 @default.
- W2023089898 cites W2134255943 @default.
- W2023089898 cites W2141123045 @default.
- W2023089898 cites W2144599826 @default.
- W2023089898 cites W2152057165 @default.
- W2023089898 cites W2152935325 @default.
- W2023089898 cites W2162415535 @default.
- W2023089898 cites W2163872054 @default.
- W2023089898 cites W2165600516 @default.
- W2023089898 cites W2171189204 @default.
- W2023089898 cites W2173271817 @default.
- W2023089898 cites W2330632487 @default.
- W2023089898 cites W2950255970 @default.
- W2023089898 cites W2950571894 @default.
- W2023089898 cites W2951047298 @default.
- W2023089898 cites W2951047692 @default.
- W2023089898 cites W2951859019 @default.
- W2023089898 cites W2952074484 @default.
- W2023089898 cites W2952454658 @default.
- W2023089898 cites W2952575943 @default.
- W2023089898 cites W2953029521 @default.
- W2023089898 cites W4234277938 @default.
- W2023089898 cites W4241267853 @default.
- W2023089898 cites W4253409455 @default.
- W2023089898 doi "https://doi.org/10.1002/chem.200701439" @default.
- W2023089898 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18186090" @default.
- W2023089898 hasPublicationYear "2008" @default.
- W2023089898 type Work @default.
- W2023089898 sameAs 2023089898 @default.
- W2023089898 citedByCount "101" @default.
- W2023089898 countsByYear W20230898982012 @default.
- W2023089898 countsByYear W20230898982013 @default.
- W2023089898 countsByYear W20230898982014 @default.
- W2023089898 countsByYear W20230898982015 @default.
- W2023089898 countsByYear W20230898982016 @default.
- W2023089898 countsByYear W20230898982017 @default.
- W2023089898 countsByYear W20230898982018 @default.
- W2023089898 countsByYear W20230898982019 @default.
- W2023089898 countsByYear W20230898982021 @default.
- W2023089898 countsByYear W20230898982022 @default.
- W2023089898 crossrefType "journal-article" @default.
- W2023089898 hasAuthorship W2023089898A5043024558 @default.
- W2023089898 hasAuthorship W2023089898A5090314981 @default.
- W2023089898 hasAuthorship W2023089898A5091855839 @default.
- W2023089898 hasConcept C116569031 @default.
- W2023089898 hasConcept C123605464 @default.
- W2023089898 hasConcept C126322002 @default.
- W2023089898 hasConcept C134195300 @default.
- W2023089898 hasConcept C135731615 @default.
- W2023089898 hasConcept C146686406 @default.
- W2023089898 hasConcept C155647269 @default.
- W2023089898 hasConcept C161790260 @default.
- W2023089898 hasConcept C164361826 @default.
- W2023089898 hasConcept C170493617 @default.
- W2023089898 hasConcept C178790620 @default.
- W2023089898 hasConcept C178907741 @default.
- W2023089898 hasConcept C185592680 @default.
- W2023089898 hasConcept C21951064 @default.
- W2023089898 hasConcept C2777327210 @default.
- W2023089898 hasConcept C2778567177 @default.
- W2023089898 hasConcept C2779692420 @default.
- W2023089898 hasConcept C2780183160 @default.
- W2023089898 hasConcept C55493867 @default.
- W2023089898 hasConcept C71240020 @default.
- W2023089898 hasConcept C71799276 @default.
- W2023089898 hasConcept C71924100 @default.