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- W2023096684 abstract "The acute and subacute toxicity studies on 2,3-dichloropropionic acid and chlorinated polyacrylamide, which are probably produced during the chlorination of a drinking water treatment system, were conducted in comparison with their original compounds, acrylamide and polyacrylamide using young Wistar rats in order to evaluate the safety of drinking water. The LD50 (mg/kg body wt) values were found to be 177 and 141 for acrylamide, 470 and 289 for 2,3-dichloropropionic acid, > 1000 and > 1000 for polyacrylamide and > 1000 and > 1000 for chlorinated polyacrylamide, respectively, in male and female rats. The 28 day-toxicity tests on acrylamide, 2,3-dichloropropionic acid, polyacrylamide and chlorinated polyacrylamide were conducted using male rats. By feeding 340 ppm acrylamide, growth was delayed during the first 19 days and then ceased when paralysis of hindlimb was observed. Severe retardation of growth was observed from the onset when treated with 700 ppm. However, toxicity was weak when half doses of either acrylamide or 2,3-dichloropropionic acid were given. Feeding polyacrylamide or chlorinated polyacrylamide at doses of 2500 or 10,000 ppm did not induce any considerable toxicity on the growth, gross findings, hematological and biochemical parameters. Histopathological examination revealed inhibition of spermatogenesis in rats fed 340 ppm acrylamide." @default.
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- W2023096684 title "Acute and subacute toxicity studies on 2,3-dichloropropionic acid and chlorinated polyacrylamide in rats" @default.
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- W2023096684 doi "https://doi.org/10.1016/0043-1354(90)90200-p" @default.
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