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• W2023100224 startingPage "15" @default.
• W2023100224 abstract "The selectivity of the ubiquitin–26 S proteasome system (UPS) for a particular substrate protein relies on the interaction between a ubiquitin-conjugating enzyme (E2, of which a cell contains relatively few) and a ubiquitin–protein ligase (E3, of which there are possibly hundreds). Post-translational modifications of the protein substrate, such as phosphorylation or hydroxylation, are often required prior to its selection. In this way, the precise spatio-temporal targeting and degradation of a given substrate can be achieved. The E3s are a large, diverse group of proteins, characterized by one of several defining motifs. These include a HECT (homologous to E6-associated protein C-terminus), RING (really interesting new gene) or U-box (a modified RING motif without the full complement of Zn2+-binding ligands) domain. Whereas HECT E3s have a direct role in catalysis during ubiquitination, RING and U-box E3s facilitate protein ubiquitination. These latter two E3 types act as adaptor-like molecules. They bring an E2 and a substrate into sufficiently close proximity to promote the substrate's ubiquitination. Although many RING-type E3s, such as MDM2 (murine double minute clone 2 oncoprotein) and c-Cbl, can apparently act alone, others are found as components of much larger multi-protein complexes, such as the anaphase-promoting complex. Taken together, these multifaceted properties and interactions enable E3s to provide a powerful, and specific, mechanism for protein clearance within all cells of eukaryotic organisms. The importance of E3s is highlighted by the number of normal cellular processes they regulate, and the number of diseases associated with their loss of function or inappropriate targeting." @default.
• W2023100224 created "2016-06-24" @default.
• W2023100224 creator A5026017797 @default.
• W2023100224 creator A5066966079 @default.
• W2023100224 date "2005-12-01" @default.
• W2023100224 modified "2023-10-12" @default.
• W2023100224 title "E3 ubiquitin ligases" @default.
• W2023100224 cites W1481229588 @default.
• W2023100224 cites W1497941038 @default.
• W2023100224 cites W1524830325 @default.
• W2023100224 cites W1529474377 @default.
• W2023100224 cites W1550876205 @default.
• W2023100224 cites W1572453332 @default.
• W2023100224 cites W1578151093 @default.
• W2023100224 cites W1592122546 @default.
• W2023100224 cites W1615913434 @default.
• W2023100224 cites W1877873625 @default.
• W2023100224 cites W1933701962 @default.
• W2023100224 cites W1963540950 @default.
• W2023100224 cites W1964021682 @default.
• W2023100224 cites W1964745905 @default.
• W2023100224 cites W1972242729 @default.
• W2023100224 cites W1974559074 @default.
• W2023100224 cites W1976154872 @default.
• W2023100224 cites W1977655579 @default.
• W2023100224 cites W1982492614 @default.
• W2023100224 cites W1982756071 @default.
• W2023100224 cites W1987927755 @default.
• W2023100224 cites W1988031203 @default.
• W2023100224 cites W1989842375 @default.
• W2023100224 cites W1992256487 @default.
• W2023100224 cites W1992577657 @default.
• W2023100224 cites W1996422344 @default.
• W2023100224 cites W1996957169 @default.
• W2023100224 cites W2001230287 @default.
• W2023100224 cites W2001941537 @default.
• W2023100224 cites W2006905408 @default.
• W2023100224 cites W2009417817 @default.
• W2023100224 cites W2009818561 @default.
• W2023100224 cites W2011433742 @default.
• W2023100224 cites W2013558716 @default.
• W2023100224 cites W2023578962 @default.
• W2023100224 cites W2026055716 @default.
• W2023100224 cites W2026582738 @default.
• W2023100224 cites W2036012693 @default.
• W2023100224 cites W2037741527 @default.
• W2023100224 cites W2040099865 @default.
• W2023100224 cites W2043081385 @default.
• W2023100224 cites W2046217944 @default.
• W2023100224 cites W2047211900 @default.
• W2023100224 cites W2050824263 @default.
• W2023100224 cites W2054468092 @default.
• W2023100224 cites W2055809895 @default.
• W2023100224 cites W2059540409 @default.
• W2023100224 cites W2066341927 @default.
• W2023100224 cites W2069719894 @default.
• W2023100224 cites W2074298687 @default.
• W2023100224 cites W2075059777 @default.
• W2023100224 cites W2075470465 @default.
• W2023100224 cites W2084483488 @default.
• W2023100224 cites W2086134353 @default.
• W2023100224 cites W2091279967 @default.
• W2023100224 cites W2100913143 @default.
• W2023100224 cites W2101362932 @default.
• W2023100224 cites W2103022330 @default.
• W2023100224 cites W2106188734 @default.
• W2023100224 cites W2107621770 @default.
• W2023100224 cites W2109398848 @default.
• W2023100224 cites W2109477996 @default.
• W2023100224 cites W2110780830 @default.
• W2023100224 cites W2114197914 @default.
• W2023100224 cites W2115438428 @default.
• W2023100224 cites W2118231442 @default.
• W2023100224 cites W2122140047 @default.
• W2023100224 cites W2123326494 @default.
• W2023100224 cites W2128394280 @default.
• W2023100224 cites W2131035051 @default.
• W2023100224 cites W2133316176 @default.
• W2023100224 cites W2135792781 @default.
• W2023100224 cites W2138450406 @default.
• W2023100224 cites W2140660269 @default.
• W2023100224 cites W2141227147 @default.
• W2023100224 cites W2143733560 @default.
• W2023100224 cites W2145683656 @default.
• W2023100224 cites W2145858879 @default.
• W2023100224 cites W2148633064 @default.
• W2023100224 cites W2151439322 @default.
• W2023100224 cites W2154539611 @default.
• W2023100224 cites W2165378784 @default.
• W2023100224 cites W2167485048 @default.
• W2023100224 cites W2170028943 @default.
• W2023100224 cites W2170939558 @default.
• W2023100224 cites W2171483783 @default.
• W2023100224 cites W2289738561 @default.
• W2023100224 cites W2301145210 @default.
• W2023100224 cites W2434040100 @default.
• W2023100224 cites W2485777077 @default.
• W2023100224 cites W2626064592 @default.

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