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• W2023101044 abstract "A morphological study was performed on 27 human placentas from normal gestations (Group 1) and compared with those from eight cases of intrauterine growth restriction (IUGR) (Group 2). Semithin section light microscopy, transmission, and scanning electron microscopy were carried out on trophoblastic terminal villi, carefully identified under the stereomicroscope. In growth retardation cases, villi appear longer, thinner, and less vascularized, compared to the normal condition. Fibrinoid, an extracellular material of hematic origin, frequently fills villar stroma. The density of apical microvilli appears considerably reduced and occasional microvilli-free areas are observed in growth retardation cases. Moreover, the underlying basal membrane appears significantly thicker than that of normal syncytiotrophoblast. Recently, particular attention has been paid to apoptosis as a possible cell deletion mechanism in growth restriction. In our study, a majority of typical apoptotic features appear indifferently in both IUGR and normal pregnancy. Our data hints that growth retardation might be correlated with a complex of structural changes, suggestive of maternofetal traffic downregulation, but further studies are required to understand the underlying functional mechanisms. Microsc. Res. Tech. 65:150–158, 2004. © 2004 Wiley-Liss, Inc." @default.
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• W2023101044 date "2004-01-01" @default.
• W2023101044 modified "2023-10-01" @default.
• W2023101044 title "Ultrastructural study on human placenta from intrauterine growth retardation cases" @default.
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• W2023101044 doi "https://doi.org/10.1002/jemt.20120" @default.
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