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- W2023101273 endingPage "280" @default.
- W2023101273 startingPage "269" @default.
- W2023101273 abstract "Histamine-2 receptor antagonists (H2RA) and proton pump inhibitors (PPI) are frequently used to prevent stress-related mucosal bleeding (SRMB). A paucity of data implicates these agents with pneumonia and Clostridium difficile infection (CDI).This review comparatively evaluates the effectiveness of H2RAs and PPIs and delineates their associations with these infectious complications. A literature review through 30 September 2014 was performed.The rate of SRMB is declining, likely due better resuscitation strategies and the early provision of enteral nutrition. Therefore, gastric acid-suppressing therapies arguably reduce SRMB. However, they may contribute to pneumonia and CDI. The risks of these infectious complications depend on the extent of acid suppression and may vary by patient population. PPIs are associated with the greatest hazard for these infections, likely because they provide stronger acid suppression. Intermittent administration of H2RAs has theoretical advantages over continuous H2RA or PPI therapies as this dosing strategy does not fully suppress gastric acid and may limit infection risk. Placebo-controlled studies are warranted because clinical equipoise exists as the detrimental outcomes of these infections may outweigh the benefit of preventing SRMB given the infrequent occurrence of SRMB." @default.
- W2023101273 created "2016-06-24" @default.
- W2023101273 creator A5040757935 @default.
- W2023101273 creator A5077824195 @default.
- W2023101273 creator A5081967924 @default.
- W2023101273 creator A5082697782 @default.
- W2023101273 date "2014-11-25" @default.
- W2023101273 modified "2023-10-06" @default.
- W2023101273 title "Proton pump inhibitors and histamine-2 receptor antagonists in the intensive care setting: focus on therapeutic and adverse events" @default.
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