FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023105417> ?p ?o ?g. }

• W2023105417 endingPage "309" @default.
• W2023105417 startingPage "303" @default.
• W2023105417 abstract "Endothelin-1 causes long-lasting contraction via endothelin type A receptor (ETAR) in isolated rat mesenteric arteries (RMA) that cannot be readily terminated by removing the agonist, or by adding the ETAR antagonist BQ123 or the NO donor sodium nitroprusside. It could be terminated by adding calcitonin-gene related peptide (CGRP), most likely because CGRP causes ET-1/ETAR dissociation. Here we investigated this phenomenon in human coronary microarteries (HCMA). We simultaneously verified the effects of CGRP in RMA and HCMA towards other vasoconstrictors, i.e., the α1-adrenoceptor agonist phenylephrine, the thromboxane A2 analog U46619 (9,11-dideoxy-11α,9α-epoxy-methano-prostaglandin F2α) and KCl. Long-lasting contraction (remaining after washing away the agonist) was observed for ET-1 in RMA, but not HCMA. Constrictions to phenylephrine, U46619 or KCl did not last upon washing. When added on top of ET-1-initiated contraction in RMA, CGRP effectively counteracted vasoconstriction, i.e., it caused full relaxation. Inhibitory effects of CGRP were also observed when briefly exposing RMA and HCMA to CGRP 1h before the addition of ET-1. Similar inhibitory effects of transient CGRP pre-incubation were seen towards phenylephrine, U46619 or KCl in RMA and HCMA. In conclusion, our data imply that CGRP, like ET-1, causes long-lasting effects that remain apparent up to 1h after its removal from the organ bath. Thus, in addition to the reported dissociation of ET-1/ETAR complexes, CGRP causes long-lasting non-selective arterial smooth muscle relaxation that may add to the neuropeptide being a physiological antagonist of arterial effects of ET-1. Long-lasting, washout-resistant ET-1/ETAR interaction does not occur in HCMAs." @default.
• W2023105417 created "2016-06-24" @default.
• W2023105417 creator A5012410111 @default.
• W2023105417 creator A5046295598 @default.
• W2023105417 creator A5049359215 @default.
• W2023105417 creator A5067934545 @default.
• W2023105417 creator A5068995309 @default.
• W2023105417 creator A5075999664 @default.
• W2023105417 creator A5078543779 @default.
• W2023105417 date "2013-11-01" @default.
• W2023105417 modified "2023-10-02" @default.
• W2023105417 title "Long-lasting physiological antagonism of calcitonin gene-related peptide towards endothelin-1 in rat mesenteric arteries and human coronary arteries" @default.
• W2023105417 cites W1538946196 @default.
• W2023105417 cites W1877010292 @default.
• W2023105417 cites W1970445852 @default.
• W2023105417 cites W1987320752 @default.
• W2023105417 cites W1990461933 @default.
• W2023105417 cites W1991722003 @default.
• W2023105417 cites W2061196813 @default.
• W2023105417 cites W2074289890 @default.
• W2023105417 cites W2082033247 @default.
• W2023105417 cites W2086040184 @default.
• W2023105417 cites W2088245326 @default.
• W2023105417 cites W2092296830 @default.
• W2023105417 cites W2093655696 @default.
• W2023105417 cites W2102917831 @default.
• W2023105417 cites W2106725903 @default.
• W2023105417 cites W2112795086 @default.
• W2023105417 cites W2117288014 @default.
• W2023105417 cites W2133954273 @default.
• W2023105417 cites W2150276386 @default.
• W2023105417 cites W2167077199 @default.
• W2023105417 cites W2170847710 @default.
• W2023105417 cites W2325922472 @default.
• W2023105417 doi "https://doi.org/10.1016/j.ejphar.2013.10.012" @default.
• W2023105417 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24140435" @default.
• W2023105417 hasPublicationYear "2013" @default.
• W2023105417 type Work @default.
• W2023105417 sameAs 2023105417 @default.
• W2023105417 citedByCount "9" @default.
• W2023105417 countsByYear W20231054172014 @default.
• W2023105417 countsByYear W20231054172015 @default.
• W2023105417 countsByYear W20231054172016 @default.
• W2023105417 countsByYear W20231054172017 @default.
• W2023105417 countsByYear W20231054172019 @default.
• W2023105417 crossrefType "journal-article" @default.
• W2023105417 hasAuthorship W2023105417A5012410111 @default.
• W2023105417 hasAuthorship W2023105417A5046295598 @default.
• W2023105417 hasAuthorship W2023105417A5049359215 @default.
• W2023105417 hasAuthorship W2023105417A5067934545 @default.
• W2023105417 hasAuthorship W2023105417A5068995309 @default.
• W2023105417 hasAuthorship W2023105417A5075999664 @default.
• W2023105417 hasAuthorship W2023105417A5078543779 @default.
• W2023105417 hasConcept C118303440 @default.
• W2023105417 hasConcept C120770815 @default.
• W2023105417 hasConcept C126322002 @default.
• W2023105417 hasConcept C134018914 @default.
• W2023105417 hasConcept C144980905 @default.
• W2023105417 hasConcept C149601957 @default.
• W2023105417 hasConcept C163170386 @default.
• W2023105417 hasConcept C163415756 @default.
• W2023105417 hasConcept C170493617 @default.
• W2023105417 hasConcept C185592680 @default.
• W2023105417 hasConcept C2776820930 @default.
• W2023105417 hasConcept C2777952589 @default.
• W2023105417 hasConcept C2778938600 @default.
• W2023105417 hasConcept C2779961880 @default.
• W2023105417 hasConcept C2780771799 @default.
• W2023105417 hasConcept C71924100 @default.
• W2023105417 hasConcept C84393581 @default.
• W2023105417 hasConceptScore W2023105417C118303440 @default.
• W2023105417 hasConceptScore W2023105417C120770815 @default.
• W2023105417 hasConceptScore W2023105417C126322002 @default.
• W2023105417 hasConceptScore W2023105417C134018914 @default.
• W2023105417 hasConceptScore W2023105417C144980905 @default.
• W2023105417 hasConceptScore W2023105417C149601957 @default.
• W2023105417 hasConceptScore W2023105417C163170386 @default.
• W2023105417 hasConceptScore W2023105417C163415756 @default.
• W2023105417 hasConceptScore W2023105417C170493617 @default.
• W2023105417 hasConceptScore W2023105417C185592680 @default.
• W2023105417 hasConceptScore W2023105417C2776820930 @default.
• W2023105417 hasConceptScore W2023105417C2777952589 @default.
• W2023105417 hasConceptScore W2023105417C2778938600 @default.
• W2023105417 hasConceptScore W2023105417C2779961880 @default.
• W2023105417 hasConceptScore W2023105417C2780771799 @default.
• W2023105417 hasConceptScore W2023105417C71924100 @default.
• W2023105417 hasConceptScore W2023105417C84393581 @default.
• W2023105417 hasIssue "1-3" @default.
• W2023105417 hasLocation W20231054171 @default.
• W2023105417 hasLocation W20231054172 @default.
• W2023105417 hasOpenAccess W2023105417 @default.
• W2023105417 hasPrimaryLocation W20231054171 @default.
• W2023105417 hasRelatedWork W1497839532 @default.
• W2023105417 hasRelatedWork W1516809639 @default.
• W2023105417 hasRelatedWork W2044091624 @default.
• W2023105417 hasRelatedWork W2048812543 @default.
• W2023105417 hasRelatedWork W2054381541 @default.
• W2023105417 hasRelatedWork W2069028451 @default.

• next