Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023106230> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2023106230 endingPage "528" @default.
- W2023106230 startingPage "524" @default.
- W2023106230 abstract "The purpose of the study was to demonstrate how the interaction between phenytoin and tacrolimus (FK 506) can be managed clinically and to characterize the change in FK 506 levels after discontinuation of phenytoin in two Japanese heart transplant recipients with different dosing periods ofphenytoin.A drug interaction between phenytoin and FK 506 was investigated in 2 patients. The concentration-dose ratios (CDR: trough blood FK 506 level (ng/ml)/FK 506 dose (mg/day) on the previous day) were calculated as an index of the induction of the CYP3A4 enzyme during and after phenytoin therapy.About 2- to 3-fold dosages of FK 506 were required to maintain the required blood level when phenytoin was used concomitantly in the two cases examined. The FK 506 dose was constant within 21 days after discontinuing phenytoin in Patient 1 who had 36 days of phenytoin therapy. In Patient 2 with 21-day phenytoin therapy, the FK 506 doses and CDR varied for 10 days after discontinuing phenytoin, and expected FK 506 C0 levels were achieved within 11 days.The persistence of CYP induction after discontinuing phenytoin is dependent on the history of administration and, perhaps, on the dosing period in particular." @default.
- W2023106230 created "2016-06-24" @default.
- W2023106230 creator A5002256460 @default.
- W2023106230 creator A5005047248 @default.
- W2023106230 creator A5014449911 @default.
- W2023106230 creator A5044738348 @default.
- W2023106230 creator A5057753614 @default.
- W2023106230 creator A5060025662 @default.
- W2023106230 creator A5082569020 @default.
- W2023106230 creator A5084097657 @default.
- W2023106230 date "2007-09-01" @default.
- W2023106230 modified "2023-09-23" @default.
- W2023106230 title "Drug interactions between tacrolimus and phenytoin in Japanese heart transplant recipients: 2 case reports" @default.
- W2023106230 doi "https://doi.org/10.5414/cpp45524" @default.
- W2023106230 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17907595" @default.
- W2023106230 hasPublicationYear "2007" @default.
- W2023106230 type Work @default.
- W2023106230 sameAs 2023106230 @default.
- W2023106230 citedByCount "16" @default.
- W2023106230 countsByYear W20231062302012 @default.
- W2023106230 countsByYear W20231062302013 @default.
- W2023106230 countsByYear W20231062302016 @default.
- W2023106230 countsByYear W20231062302017 @default.
- W2023106230 countsByYear W20231062302020 @default.
- W2023106230 countsByYear W20231062302021 @default.
- W2023106230 countsByYear W20231062302022 @default.
- W2023106230 crossrefType "journal-article" @default.
- W2023106230 hasAuthorship W2023106230A5002256460 @default.
- W2023106230 hasAuthorship W2023106230A5005047248 @default.
- W2023106230 hasAuthorship W2023106230A5014449911 @default.
- W2023106230 hasAuthorship W2023106230A5044738348 @default.
- W2023106230 hasAuthorship W2023106230A5057753614 @default.
- W2023106230 hasAuthorship W2023106230A5060025662 @default.
- W2023106230 hasAuthorship W2023106230A5082569020 @default.
- W2023106230 hasAuthorship W2023106230A5084097657 @default.
- W2023106230 hasConcept C112705442 @default.
- W2023106230 hasConcept C118552586 @default.
- W2023106230 hasConcept C126322002 @default.
- W2023106230 hasConcept C19831878 @default.
- W2023106230 hasConcept C2775858608 @default.
- W2023106230 hasConcept C2777288759 @default.
- W2023106230 hasConcept C2778186239 @default.
- W2023106230 hasConcept C2778337148 @default.
- W2023106230 hasConcept C2778715236 @default.
- W2023106230 hasConcept C2780035454 @default.
- W2023106230 hasConcept C2780272996 @default.
- W2023106230 hasConcept C2909675724 @default.
- W2023106230 hasConcept C2911091166 @default.
- W2023106230 hasConcept C42219234 @default.
- W2023106230 hasConcept C71924100 @default.
- W2023106230 hasConcept C97320921 @default.
- W2023106230 hasConcept C98274493 @default.
- W2023106230 hasConceptScore W2023106230C112705442 @default.
- W2023106230 hasConceptScore W2023106230C118552586 @default.
- W2023106230 hasConceptScore W2023106230C126322002 @default.
- W2023106230 hasConceptScore W2023106230C19831878 @default.
- W2023106230 hasConceptScore W2023106230C2775858608 @default.
- W2023106230 hasConceptScore W2023106230C2777288759 @default.
- W2023106230 hasConceptScore W2023106230C2778186239 @default.
- W2023106230 hasConceptScore W2023106230C2778337148 @default.
- W2023106230 hasConceptScore W2023106230C2778715236 @default.
- W2023106230 hasConceptScore W2023106230C2780035454 @default.
- W2023106230 hasConceptScore W2023106230C2780272996 @default.
- W2023106230 hasConceptScore W2023106230C2909675724 @default.
- W2023106230 hasConceptScore W2023106230C2911091166 @default.
- W2023106230 hasConceptScore W2023106230C42219234 @default.
- W2023106230 hasConceptScore W2023106230C71924100 @default.
- W2023106230 hasConceptScore W2023106230C97320921 @default.
- W2023106230 hasConceptScore W2023106230C98274493 @default.
- W2023106230 hasIssue "09" @default.
- W2023106230 hasLocation W20231062301 @default.
- W2023106230 hasLocation W20231062302 @default.
- W2023106230 hasOpenAccess W2023106230 @default.
- W2023106230 hasPrimaryLocation W20231062301 @default.
- W2023106230 hasRelatedWork W1985799882 @default.
- W2023106230 hasRelatedWork W2023977986 @default.
- W2023106230 hasRelatedWork W2031325622 @default.
- W2023106230 hasRelatedWork W2052463334 @default.
- W2023106230 hasRelatedWork W2076024851 @default.
- W2023106230 hasRelatedWork W2086575226 @default.
- W2023106230 hasRelatedWork W2153335219 @default.
- W2023106230 hasRelatedWork W2312493393 @default.
- W2023106230 hasRelatedWork W2420918848 @default.
- W2023106230 hasRelatedWork W50701402 @default.
- W2023106230 hasVolume "45" @default.
- W2023106230 isParatext "false" @default.
- W2023106230 isRetracted "false" @default.
- W2023106230 magId "2023106230" @default.
- W2023106230 workType "article" @default.