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• W2023107495 abstract "Oil spill responders require information on the relative toxicity of dispersed and un-dispersed oil in order to make informed decisions regarding the use of chemical dispersants during spill events. Toxicity of the water-accommodated fraction (WAF) and the chemically-enhanced WAF (CEWAF; via the dispersant Corexit 9500) of weathered Prudhoe Bay crude oil was investigated using adult and embryonic topsmelt; topsmelt are an ecologically important atherinid in California bays and estuaries and an important indicator species. Following 96-h exposures, metabolite profiles were measured using 1D 1 H nuclear magnetic resonance (NMR) spectroscopy and compared via principal component analysis. Similar metabolic profiles were obtained between WAF- and CEWAF-exposed adults and embryos. Although metabolic changes, for the adults lacked significance, significant increasing and decreasing metabolic changes were observed for embryos directly exposed. Furthermore, no mortality was observed for embryos, exposed to WAF and normal development occurred, whereas CEWAF exposed embryos lead to mortality and cardiovascular abnormalities. Observed toxicological information, specifically for developing fish, can aide resource managers in the relative risk of treating oil spills with dispersant. ▶ Similar metabolic profiles may be induced by similar dissolved hydrocarbons. ▶ PCA plots from both embryo tests display a dose–response relationship. ▶ Significant adult metabolic changes were only observed among four metabolites. ▶ WAF exposed embryos had more significant metabolic changes compared to CEWAF. ▶ No indication that 96-h exposures led to any sublethal effects." @default.
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• W2023107495 date "2012-04-01" @default.
• W2023107495 modified "2023-09-24" @default.
• W2023107495 title "NMR-based characterization of the acute metabolic effects of weathered crude and dispersed oil in spawning topsmelt and their embryos" @default.
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• W2023107495 doi "https://doi.org/10.1016/j.ecoenv.2011.11.009" @default.
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