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- W2023109134 abstract "ABSTRACT: Prostate tissue contains high concentrations of zinc. Zinc content in the prostate gland changes in prostatic disease, such as benign prostate hyperplasia and prostate cancer, which occur more frequently with increasing age. Prostate zinc content is also known to decrease after castration in animal models. It is not clear how prostate zinc content is regulated; therefore, to clarify the mechanisms underlying zinc homeostasis, we examined zinc content and the expression of zinc transporters and metallothioneins in the prostates of aged or castrated rats. Zinc concentration was measured by flame atomic absorption spectrometry. The mRNA expression of zinc transporters and metallothioneins was determined by real‐time reverse transcriptase polymerase chain reaction analysis. The expression of the zinc transporter Slc30a2 ( Znt2 ) in ventral prostate (VP) of aged rats (21 months) was approximately 21‐fold higher than that in VP of young rats (4 months), and zinc levels in VP of young rats increased significantly compared with that in aged rats. Zinc content in lateral prostate (LP) and dorsal prostate did not differ between young and aged rats. Decreased metallothionein‐3 ( Mt3 ) expression was observed in LP of castrated rats, and this reduction was prevented by testosterone replacement. Zinc content and Mt3 expression levels correlated significantly in rat LP. Our findings suggest that Mt3 could play a critical role in zinc homeostasis in rat LP." @default.
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- W2023109134 date "2011-03-04" @default.
- W2023109134 modified "2023-10-18" @default.
- W2023109134 title "Castration- and Aging-Induced Changes in the Expression of Zinc Transporter and Metallothionein in Rat Prostate" @default.
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- W2023109134 doi "https://doi.org/10.2164/jandrol.110.011205" @default.
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