FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023112894> ?p ?o ?g. }

• W2023112894 endingPage "664" @default.
• W2023112894 startingPage "660" @default.
• W2023112894 abstract "Sixteen healthy, nonsmoking adult males participated in a randomized, double-blind, placebo-controlled, two-way crossover study to evaluate the influence of chronic lomefloxacin administration on the disposition of caffeine and its major metabolite, paraxanthine, at steady-state conditions. Lomefloxacin (400 mg) or placebo was administered orally once daily for 5 days to xanthine-free volunteers after an overnight fast. Caffeine (200 mg orally) was administered simultaneously with lomefloxacin on days 3 through 5. After a 2-day washout period, subjects were crossed over to the alternate 5-day regimen with caffeine, which was again given on the final 3 days. Blood samples for caffeine, paraxanthine, and lomefloxacin concentration determinations were serially collected for 48 h following the last dose of each regimen. All compounds were analyzed by high-performance liquid chromatography. For the placebo versus lomefloxacin-containing treatments, maximum caffeine concentrations in plasma (4.35 +/- 0.63 versus 4.07 +/- 0.56 micrograms/ml), areas under the concentration-time curve from time zero to 24 h at steady state (30.3 +/- 6.9 versus 29.7 +/- 6.6 micrograms.h/ml), and elimination half-lives of caffeine (4.8 +/- 1.1 versus 4.8 +/- 1.2 h) were not significantly different. In addition, there were no significant changes in the disposition parameters of paraxanthine as a result of lomefloxacin administration. The frequencies of central nervous system-related effects for the two treatments were not statistically different. We conclude that lomefloxacin has no significant effect on the disposition of caffeine in young healthy volunteers." @default.
• W2023112894 created "2016-06-24" @default.
• W2023112894 creator A5041512306 @default.
• W2023112894 creator A5046524498 @default.
• W2023112894 creator A5079213208 @default.
• W2023112894 creator A5081751806 @default.
• W2023112894 date "1991-04-01" @default.
• W2023112894 modified "2023-10-17" @default.
• W2023112894 title "Lack of interaction between lomefloxacin and caffeine in normal volunteers" @default.
• W2023112894 cites W175955759 @default.
• W2023112894 cites W17845734 @default.
• W2023112894 cites W1963848060 @default.
• W2023112894 cites W1972200239 @default.
• W2023112894 cites W1976518821 @default.
• W2023112894 cites W1980061996 @default.
• W2023112894 cites W1984824250 @default.
• W2023112894 cites W1989280559 @default.
• W2023112894 cites W1997673867 @default.
• W2023112894 cites W2002118624 @default.
• W2023112894 cites W2020038039 @default.
• W2023112894 cites W2021165525 @default.
• W2023112894 cites W2040325671 @default.
• W2023112894 cites W2043402035 @default.
• W2023112894 cites W2043929828 @default.
• W2023112894 cites W2044472341 @default.
• W2023112894 cites W2050824432 @default.
• W2023112894 cites W2053052455 @default.
• W2023112894 cites W2060518425 @default.
• W2023112894 cites W2079520876 @default.
• W2023112894 cites W2085290387 @default.
• W2023112894 cites W2093930484 @default.
• W2023112894 cites W2094781861 @default.
• W2023112894 cites W2129230422 @default.
• W2023112894 cites W2166221277 @default.
• W2023112894 doi "https://doi.org/10.1128/aac.35.4.660" @default.
• W2023112894 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/245075" @default.
• W2023112894 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2069371" @default.
• W2023112894 hasPublicationYear "1991" @default.
• W2023112894 type Work @default.
• W2023112894 sameAs 2023112894 @default.
• W2023112894 citedByCount "22" @default.
• W2023112894 countsByYear W20231128942014 @default.
• W2023112894 countsByYear W20231128942018 @default.
• W2023112894 countsByYear W20231128942021 @default.
• W2023112894 countsByYear W20231128942022 @default.
• W2023112894 crossrefType "journal-article" @default.
• W2023112894 hasAuthorship W2023112894A5041512306 @default.
• W2023112894 hasAuthorship W2023112894A5046524498 @default.
• W2023112894 hasAuthorship W2023112894A5079213208 @default.
• W2023112894 hasAuthorship W2023112894A5081751806 @default.
• W2023112894 hasBestOaLocation W20231128941 @default.
• W2023112894 hasConcept C112705442 @default.
• W2023112894 hasConcept C126322002 @default.
• W2023112894 hasConcept C142724271 @default.
• W2023112894 hasConcept C185592680 @default.
• W2023112894 hasConcept C204787440 @default.
• W2023112894 hasConcept C27081682 @default.
• W2023112894 hasConcept C2776768635 @default.
• W2023112894 hasConcept C2777056448 @default.
• W2023112894 hasConcept C2777477808 @default.
• W2023112894 hasConcept C2778049240 @default.
• W2023112894 hasConcept C2778095195 @default.
• W2023112894 hasConcept C2778162141 @default.
• W2023112894 hasConcept C2778500429 @default.
• W2023112894 hasConcept C2778512257 @default.
• W2023112894 hasConcept C2778923102 @default.
• W2023112894 hasConcept C501593827 @default.
• W2023112894 hasConcept C526171541 @default.
• W2023112894 hasConcept C55493867 @default.
• W2023112894 hasConcept C62231903 @default.
• W2023112894 hasConcept C6557445 @default.
• W2023112894 hasConcept C71924100 @default.
• W2023112894 hasConcept C86745063 @default.
• W2023112894 hasConcept C86803240 @default.
• W2023112894 hasConcept C87813604 @default.
• W2023112894 hasConcept C98274493 @default.
• W2023112894 hasConceptScore W2023112894C112705442 @default.
• W2023112894 hasConceptScore W2023112894C126322002 @default.
• W2023112894 hasConceptScore W2023112894C142724271 @default.
• W2023112894 hasConceptScore W2023112894C185592680 @default.
• W2023112894 hasConceptScore W2023112894C204787440 @default.
• W2023112894 hasConceptScore W2023112894C27081682 @default.
• W2023112894 hasConceptScore W2023112894C2776768635 @default.
• W2023112894 hasConceptScore W2023112894C2777056448 @default.
• W2023112894 hasConceptScore W2023112894C2777477808 @default.
• W2023112894 hasConceptScore W2023112894C2778049240 @default.
• W2023112894 hasConceptScore W2023112894C2778095195 @default.
• W2023112894 hasConceptScore W2023112894C2778162141 @default.
• W2023112894 hasConceptScore W2023112894C2778500429 @default.
• W2023112894 hasConceptScore W2023112894C2778512257 @default.
• W2023112894 hasConceptScore W2023112894C2778923102 @default.
• W2023112894 hasConceptScore W2023112894C501593827 @default.
• W2023112894 hasConceptScore W2023112894C526171541 @default.
• W2023112894 hasConceptScore W2023112894C55493867 @default.
• W2023112894 hasConceptScore W2023112894C62231903 @default.
• W2023112894 hasConceptScore W2023112894C6557445 @default.
• W2023112894 hasConceptScore W2023112894C71924100 @default.
• W2023112894 hasConceptScore W2023112894C86745063 @default.

• next