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- W2023113304 abstract "Abstract Rats were injected intraperitoneally with single doses of styrene. Its effects on the kinetic parameters of liver microsomal monooxygenases and epoxide hydratase were investigated. The results were compared with those produced either by ethylbenzene, the vinyl-saturated analog of styrene or by phenobarbital and 3-methylcholanthrene, the classical inducers of those enzymes. The biochemical modifications were correlated with the altered ability of homogenates obtained from similarly pretreated rats to activate benzo(a)pyrene into intermediates mutagenic towards Salmonella typhimurium . Administration of styrene or 3-methylcholanthrene decreased the K m , of benzo(a)pyrene hydroxylase and aldrin epoxidase; styrene, but not 3-methylcholanthrene, decreased the K m of styrene oxide hydratase; none of the two compounds modified the K m of styrene epoxidase. Pretreatment of the rats by styrene or 3-methylcholanthrene enhanced the S 9 mediated mutagenicity of benzo(a)pyrene several-fold, when compared to the mutagenic response mediated by liver preparations from control rats. Phenobarbital and ethylbenzene did not modify either the K m of the investigated enzymes or the liver-mediated mutagenicity of benzo(a)pyrene." @default.
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- W2023113304 date "1979-05-01" @default.
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- W2023113304 title "Styrene induced modifications of some rat liver enzymes involved in the activation and inactivation of xenobiotics" @default.
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- W2023113304 doi "https://doi.org/10.1016/0006-2952(79)90179-5" @default.
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