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- W2023113399 abstract "Little is known about elders who experience long-term maintenance of cognitive function. Furthermore, whether maintenance of cognitive function is associated with health advantages such as lower mortality or incident disability is unclear. We studied 2733 elders (mean age 74 years at baseline; 80 years at follow-up) participating in a longitudinal study of aging. Cognition was measured with the Modified Mini-Mental State Examination (3MS), a test of global cognition, and we included participants who had testing at least 2 times. We defined three cognitive groups based on 4-year participant-specific slopes (“maintainers” with a positive or 0 slope, “typical decliners” with slope <0 but <1sd below the mean and “major decliners” with slope ≥1sd below the mean). We then determined if cognitive group was associated with death and incident physical disability (difficulty with activities of daily living or mobility) during the subsequent 3 years. 984 (36%) were maintainers, 1314 (48%) typical decliners, and 435 (16%) major decliners. Compared to those with typical decline, elders who maintained cognition had lower mortality (7% vs 14%, hazard ratio (HR) =0.48; 95%CI 0.36–0.63) and incident disability (22% vs 29%, HR=0.74; 95% CI=0.62–0.89). After adjustment for age, race, gender, education, APOE e4, depression, body mass index, stroke, hypertension and diabetes, these differences remained. As expected, those with major cognitive decline had greater mortality (20%) and incident disability (40%) compared to those with typical decline. A substantial proportion of elders maintain cognitive function in their eighth and ninth decades of life. These elders demonstrate lower risk of death and functional decline than those with minor cognitive decline supporting the concept of “successful” cognitive aging." @default.
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- W2023113399 date "2008-07-01" @default.
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- W2023113399 title "P4-129: The impact of maintaining cognitive function on disability and death" @default.
- W2023113399 doi "https://doi.org/10.1016/j.jalz.2008.05.2195" @default.
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