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- W2023118502 abstract "A protein of Mr 25–40 kilodaltons in normal human plasma binds human corticotropin-releasing hormone (hCRH), but not ovine CRH. Binding requires both N- and C-terminal hCRH sequences and has a Kd of 2 × 10−10 M and a binding site concentration of 1.4 pmoles per ml of plasma. Its binding is not affected by heating to 56°C for 1 h, but is abolished by exposure to 6 M guanidine-HCl, 10 mM dithiothreitol. Binding proceeds rapidly at 37°C and is 75% complete within 4 min. Neither rat nor sheep plasma appears to contain a CRH-binding protein. CRH-binding protein may explain the brief biological action of hCRH as compared to ovine CRH in man and why high concentrations of plasma immunoreactive hCRH in women during third-trimester pregnancy do not cause increased ACTH secretion." @default.
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- W2023118502 title "Specific high-affinity binding protein for human corticotropin-releasing hormone in normal human plasma" @default.
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- W2023118502 doi "https://doi.org/10.1016/0006-291x(87)91369-6" @default.
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