FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023121536> ?p ?o ?g. }

• W2023121536 endingPage "158" @default.
• W2023121536 startingPage "154" @default.
• W2023121536 abstract "Dietary beta-glucans lower the blood concentrations of cholesterol in animals and humans. Recent studies have uncovered mechanisms by which dietary beta-glucans may regulate cholesterol homeostasis. There is evidence that beta-glucans sequester bile acids in the intestine, reducing their reabsorption and return to the liver. Reducing hepatic bile acid concentrations activates the enzyme CYP7A1, which converts cholesterol into bile acids. This action leads to a reduction of hepatic cell cholesterol content, which up-regulates low-density lipoprotein (LDL) receptor synthesis and thereby accelerates the transportation of LDL-cholesterol from the blood into hepatocytes. Reduced intracellular cholesterol also up-regulates the hepatic synthesis of 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme in cholesterol synthesis. Statins inhibit 3-hydroxy-3-methylglutaryl coenzyme A reductase and could therefore provide an additive effect in suppressing hepatocyte cholesterol to that produced by enhancing its depletion with beta-glucans. Through this combination of agents, one would expect a greater clearance of LDL from the plasma with lower steady state levels of LDL-cholesterol." @default.
• W2023121536 created "2016-06-24" @default.
• W2023121536 creator A5002681207 @default.
• W2023121536 creator A5058107287 @default.
• W2023121536 date "2009-05-01" @default.
• W2023121536 modified "2023-10-14" @default.
• W2023121536 title "The effects of diets enriched in beta-glucans on blood lipoprotein concentrations" @default.
• W2023121536 cites W1575242432 @default.
• W2023121536 cites W1824772234 @default.
• W2023121536 cites W1954086462 @default.
• W2023121536 cites W1957123899 @default.
• W2023121536 cites W1967684902 @default.
• W2023121536 cites W1981770848 @default.
• W2023121536 cites W1992166522 @default.
• W2023121536 cites W2010124851 @default.
• W2023121536 cites W2016632049 @default.
• W2023121536 cites W2029653089 @default.
• W2023121536 cites W2033053171 @default.
• W2023121536 cites W2033381350 @default.
• W2023121536 cites W2036466475 @default.
• W2023121536 cites W2041166090 @default.
• W2023121536 cites W2049923699 @default.
• W2023121536 cites W2053946842 @default.
• W2023121536 cites W2055795096 @default.
• W2023121536 cites W2063229703 @default.
• W2023121536 cites W2066543603 @default.
• W2023121536 cites W2066995310 @default.
• W2023121536 cites W2093201670 @default.
• W2023121536 cites W2093608891 @default.
• W2023121536 cites W2103403492 @default.
• W2023121536 cites W2104215271 @default.
• W2023121536 cites W2108093856 @default.
• W2023121536 cites W2108268914 @default.
• W2023121536 cites W2122135483 @default.
• W2023121536 cites W2122982394 @default.
• W2023121536 cites W2127958769 @default.
• W2023121536 cites W2135750241 @default.
• W2023121536 cites W2147542963 @default.
• W2023121536 cites W2149134000 @default.
• W2023121536 cites W2157456076 @default.
• W2023121536 cites W2158609797 @default.
• W2023121536 doi "https://doi.org/10.1016/j.jacl.2009.04.054" @default.
• W2023121536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21291810" @default.
• W2023121536 hasPublicationYear "2009" @default.
• W2023121536 type Work @default.
• W2023121536 sameAs 2023121536 @default.
• W2023121536 citedByCount "42" @default.
• W2023121536 countsByYear W20231215362012 @default.
• W2023121536 countsByYear W20231215362013 @default.
• W2023121536 countsByYear W20231215362014 @default.
• W2023121536 countsByYear W20231215362015 @default.
• W2023121536 countsByYear W20231215362016 @default.
• W2023121536 countsByYear W20231215362017 @default.
• W2023121536 countsByYear W20231215362018 @default.
• W2023121536 countsByYear W20231215362019 @default.
• W2023121536 countsByYear W20231215362020 @default.
• W2023121536 countsByYear W20231215362021 @default.
• W2023121536 countsByYear W20231215362023 @default.
• W2023121536 crossrefType "journal-article" @default.
• W2023121536 hasAuthorship W2023121536A5002681207 @default.
• W2023121536 hasAuthorship W2023121536A5058107287 @default.
• W2023121536 hasConcept C104950815 @default.
• W2023121536 hasConcept C110459506 @default.
• W2023121536 hasConcept C126322002 @default.
• W2023121536 hasConcept C134018914 @default.
• W2023121536 hasConcept C134651460 @default.
• W2023121536 hasConcept C181199279 @default.
• W2023121536 hasConcept C185592680 @default.
• W2023121536 hasConcept C202751555 @default.
• W2023121536 hasConcept C2776200302 @default.
• W2023121536 hasConcept C2778163477 @default.
• W2023121536 hasConcept C2779123261 @default.
• W2023121536 hasConcept C2779399885 @default.
• W2023121536 hasConcept C2780072125 @default.
• W2023121536 hasConcept C43554185 @default.
• W2023121536 hasConcept C55493867 @default.
• W2023121536 hasConcept C71924100 @default.
• W2023121536 hasConcept C89673097 @default.
• W2023121536 hasConceptScore W2023121536C104950815 @default.
• W2023121536 hasConceptScore W2023121536C110459506 @default.
• W2023121536 hasConceptScore W2023121536C126322002 @default.
• W2023121536 hasConceptScore W2023121536C134018914 @default.
• W2023121536 hasConceptScore W2023121536C134651460 @default.
• W2023121536 hasConceptScore W2023121536C181199279 @default.
• W2023121536 hasConceptScore W2023121536C185592680 @default.
• W2023121536 hasConceptScore W2023121536C202751555 @default.
• W2023121536 hasConceptScore W2023121536C2776200302 @default.
• W2023121536 hasConceptScore W2023121536C2778163477 @default.
• W2023121536 hasConceptScore W2023121536C2779123261 @default.
• W2023121536 hasConceptScore W2023121536C2779399885 @default.
• W2023121536 hasConceptScore W2023121536C2780072125 @default.
• W2023121536 hasConceptScore W2023121536C43554185 @default.
• W2023121536 hasConceptScore W2023121536C55493867 @default.
• W2023121536 hasConceptScore W2023121536C71924100 @default.
• W2023121536 hasConceptScore W2023121536C89673097 @default.
• W2023121536 hasIssue "3" @default.
• W2023121536 hasLocation W20231215361 @default.
• W2023121536 hasLocation W20231215362 @default.

• next