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- W2023122955 abstract "Coumarins are plant secondary metabolites that have demonstrated a variety of important therapeutic properties, such as antibacterial, anti-inflammatory, and anti-coagulant effects, as well as anti-cancer and anti-AIDS activities. However, knowledge regarding their biosynthesis is relatively limited even for the simplest coumarin molecule, which serves as the gateway molecule to many pharmaceutically important coumarin derivatives. Here we reported the design and validation of artificial pathways leading to the biosynthesis of plant-specific simple coumarins in bacteria. First, Escherichia coli strains were engineered to convert inexpensive phenylpropanoid acid precursors, 4-coumarate and ferulate to simple coumarins, umbelliferone (4.3 mg/L) and scopoletin (27.8 mg/L), respectively. Furthermore, we assembled the complete artificial pathways in E. coli and achieved de novo biosynthesis of umbelliferone and scopoletin without addition of precursors. This study lays the foundation for microbial production of more diverse coumarin compounds." @default.
- W2023122955 created "2016-06-24" @default.
- W2023122955 creator A5013378849 @default.
- W2023122955 creator A5050738451 @default.
- W2023122955 creator A5051098970 @default.
- W2023122955 creator A5051418724 @default.
- W2023122955 date "2013-07-01" @default.
- W2023122955 modified "2023-10-05" @default.
- W2023122955 title "Combinatorial biosynthesis of plant-specific coumarins in bacteria" @default.
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- W2023122955 doi "https://doi.org/10.1016/j.ymben.2013.04.004" @default.
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