FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023124600> ?p ?o ?g. }

• W2023124600 endingPage "10" @default.
• W2023124600 startingPage "3" @default.
• W2023124600 abstract "Summary Background Candida spp. are the most common opportunistic fungal pathogens in humans. Oral Candida infection has been reported to be increased with pulmonary tuberculosis patients. Extracellular hydrolytic enzymes seem to play an important role in candidal overgrowth. Objective To determine the enzymatic activity and to investigate the distribution of phospholipase C (PLC) gene among the Candida isolates from patients with pulmonary tuberculosis and non tuberculosis patients. Method The study involved a total of 62 isolates of Candida from patients with pulmonary tuberculosis (37) and non tuberculosis patients (25) of Aarupadaiveedu Medical College Hospital, Pudhucherry, India. After species identification, the isolates were analyzed for the production/activity of phospholipase C, proteinase, caseinase, lipase, gelatinase, hemolysin and hydrophobicity. In addition, the distribution of PLC gene was investigated to elucidate molecular mechanism of virulence. Results All the isolates were able to produce proteinase, caseinase and lipase. Phospholipase C, hemolytic activity and the hydrophobicity were observed as 72.9, 29.7 and 27% respectively for the isolates from the patients with pulmonary tuberculosis. The corresponding values for the isolates of non tuberculosis patients were 24, 24 and 16% respectively. Gelatinolytic activity was not observed in any of the isolates. The polymerase chain reaction (PCR) based analysis for the distribution of the PLC gene showed 94.5% for the isolates of pulmonary tuberculosis patients and 84% for the isolates of non tuberculosis patients. Appreciably, the expression of the phospholipase was observed high in Candida glabrata isolates of pulmonary tuberculosis patients over the C. glabrata strains of non tuberculosis individuals. Conclusion Candida isolates invariably showed high levels of phospholipase, proteinase, caseinase and lipase activities. Particularly, the phospholipase activity was relatively high among the isolates from pulmonary tuberculosis patients. This may be one of the virulence mechanisms of pathogenic Candida, which might get elicited during the progression of pulmonary tuberculosis. Based on the present findings, it could be envisaged that the extracellular virulence of Candida spp. might have significant functional role in the progression of secondary etiology. The PLC gene of C. glabrata was sequenced and deposited in NCBI (Accession No: EU 814636). The phylogenetic analysis of the sequences evidenced that the C. glabrata as a pathogenic strain of Candida spp." @default.
• W2023124600 created "2016-06-24" @default.
• W2023124600 creator A5005735145 @default.
• W2023124600 creator A5008551356 @default.
• W2023124600 creator A5016867239 @default.
• W2023124600 creator A5045536083 @default.
• W2023124600 creator A5052280011 @default.
• W2023124600 creator A5058842819 @default.
• W2023124600 creator A5070325723 @default.
• W2023124600 creator A5088004518 @default.
• W2023124600 date "2009-03-01" @default.
• W2023124600 modified "2023-09-27" @default.
• W2023124600 title "Phospholipase C, proteinase and hemolytic activities of Candida spp. isolated from pulmonary tuberculosis patients" @default.
• W2023124600 cites W11168101 @default.
• W2023124600 cites W1601934305 @default.
• W2023124600 cites W1940720973 @default.
• W2023124600 cites W2022531352 @default.
• W2023124600 cites W2047812849 @default.
• W2023124600 cites W2051853225 @default.
• W2023124600 cites W2095979534 @default.
• W2023124600 cites W2098166370 @default.
• W2023124600 cites W2115834673 @default.
• W2023124600 cites W2121025359 @default.
• W2023124600 cites W2125990426 @default.
• W2023124600 cites W2138620668 @default.
• W2023124600 cites W2143326683 @default.
• W2023124600 cites W2168249547 @default.
• W2023124600 cites W4292333032 @default.
• W2023124600 doi "https://doi.org/10.1016/j.mycmed.2008.11.002" @default.
• W2023124600 hasPublicationYear "2009" @default.
• W2023124600 type Work @default.
• W2023124600 sameAs 2023124600 @default.
• W2023124600 citedByCount "15" @default.
• W2023124600 countsByYear W20231246002012 @default.
• W2023124600 countsByYear W20231246002015 @default.
• W2023124600 countsByYear W20231246002016 @default.
• W2023124600 countsByYear W20231246002020 @default.
• W2023124600 countsByYear W20231246002021 @default.
• W2023124600 countsByYear W20231246002022 @default.
• W2023124600 crossrefType "journal-article" @default.
• W2023124600 hasAuthorship W2023124600A5005735145 @default.
• W2023124600 hasAuthorship W2023124600A5008551356 @default.
• W2023124600 hasAuthorship W2023124600A5016867239 @default.
• W2023124600 hasAuthorship W2023124600A5045536083 @default.
• W2023124600 hasAuthorship W2023124600A5052280011 @default.
• W2023124600 hasAuthorship W2023124600A5058842819 @default.
• W2023124600 hasAuthorship W2023124600A5070325723 @default.
• W2023124600 hasAuthorship W2023124600A5088004518 @default.
• W2023124600 hasConcept C12927208 @default.
• W2023124600 hasConcept C142724271 @default.
• W2023124600 hasConcept C181199279 @default.
• W2023124600 hasConcept C2778394675 @default.
• W2023124600 hasConcept C2781069245 @default.
• W2023124600 hasConcept C2908628106 @default.
• W2023124600 hasConcept C55493867 @default.
• W2023124600 hasConcept C71924100 @default.
• W2023124600 hasConcept C86803240 @default.
• W2023124600 hasConcept C89423630 @default.
• W2023124600 hasConceptScore W2023124600C12927208 @default.
• W2023124600 hasConceptScore W2023124600C142724271 @default.
• W2023124600 hasConceptScore W2023124600C181199279 @default.
• W2023124600 hasConceptScore W2023124600C2778394675 @default.
• W2023124600 hasConceptScore W2023124600C2781069245 @default.
• W2023124600 hasConceptScore W2023124600C2908628106 @default.
• W2023124600 hasConceptScore W2023124600C55493867 @default.
• W2023124600 hasConceptScore W2023124600C71924100 @default.
• W2023124600 hasConceptScore W2023124600C86803240 @default.
• W2023124600 hasConceptScore W2023124600C89423630 @default.
• W2023124600 hasIssue "1" @default.
• W2023124600 hasLocation W20231246001 @default.
• W2023124600 hasOpenAccess W2023124600 @default.
• W2023124600 hasPrimaryLocation W20231246001 @default.
• W2023124600 hasRelatedWork W1978993202 @default.
• W2023124600 hasRelatedWork W2366490125 @default.
• W2023124600 hasRelatedWork W2412999881 @default.
• W2023124600 hasRelatedWork W2415759662 @default.
• W2023124600 hasRelatedWork W2431515385 @default.
• W2023124600 hasRelatedWork W2584653755 @default.
• W2023124600 hasRelatedWork W2884171184 @default.
• W2023124600 hasRelatedWork W2921070821 @default.
• W2023124600 hasRelatedWork W2977782109 @default.
• W2023124600 hasRelatedWork W3215265998 @default.
• W2023124600 hasVolume "19" @default.
• W2023124600 isParatext "false" @default.
• W2023124600 isRetracted "false" @default.
• W2023124600 magId "2023124600" @default.
• W2023124600 workType "article" @default.