Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023124967> ?p ?o ?g. }
- W2023124967 abstract "Interleukin-1 (IL-1) is a potent inflammatory cytokine that can be produced by a variety of cell types throughout the body. IL-1 is a central mediator of inflammation and response to infection and the role of IL-1 signaling in adult and pediatric brain injury is becoming increasingly clear. Although the mechanisms of IL-1 expression are largely understood, the downstream effects and contributions to excitotoxicity and oxidative stress are poorly defined. Here, we present a review of mechanisms of IL-1 signaling with a focus on the role of IL-1 in perinatal brain injury. We highlight research models of perinatal brain injury and the use of interleukin-1 receptor antagonist (IL-1RA) as an agent of therapeutic potential in preventing perinatal brain injury due to exposure to inflammation." @default.
- W2023124967 created "2016-06-24" @default.
- W2023124967 creator A5021033341 @default.
- W2023124967 creator A5023440391 @default.
- W2023124967 creator A5031559341 @default.
- W2023124967 date "2014-10-07" @default.
- W2023124967 modified "2023-09-30" @default.
- W2023124967 title "Interleukin-1 Receptor Blockade in Perinatal Brain Injury" @default.
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