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- W2023125871 abstract "During protein synthesis, it is often necessary for the ribosome to form a complex with a membrane-bound channel, the SecY/Sec61 complex, in order to translocate nascent proteins across a cellular membrane. Structural data on the ribosome-channel complex are currently limited to low-resolution cryo-electron microscopy maps, including one showing a bacterial ribosome bound to a monomeric SecY complex. Using that map along with available atomic-level models of the ribosome and SecY, we have determined, through molecular dynamics flexible fitting (MDFF), an atomic-resolution model of the ribosome-channel complex. We characterized computationally the sites of ribosome-SecY interaction within the complex and determined the effect of ribosome binding on the SecY channel. We also constructed a model of a ribosome in complex with a SecY dimer by adding a second copy of SecY to the MDFF-derived model. The study involved 2.7-million-atom simulations over altogether nearly 50 ns." @default.
- W2023125871 created "2016-06-24" @default.
- W2023125871 creator A5005668075 @default.
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- W2023125871 creator A5050355254 @default.
- W2023125871 creator A5080510232 @default.
- W2023125871 creator A5087861735 @default.
- W2023125871 date "2009-11-01" @default.
- W2023125871 modified "2023-10-14" @default.
- W2023125871 title "Regulation of the Protein-Conducting Channel by a Bound Ribosome" @default.
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- W2023125871 doi "https://doi.org/10.1016/j.str.2009.09.010" @default.
- W2023125871 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2778611" @default.
- W2023125871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19913480" @default.
- W2023125871 hasPublicationYear "2009" @default.
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