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- W2023126912 startingPage "1043" @default.
- W2023126912 abstract "Mammals rely upon three ocular photoreceptors to sense light: rods, cones, and intrinsically photosensitive retinal ganglion cells (ipRGCs). Rods and cones resolve details in the visual scene. Conversely, ipRGCs integrate over time and space, primarily to support non-image vision. The integrative mechanisms of ipRGCs are enigmatic, particularly since these cells use a phototransduction motif that allows invertebrates like Drosophila to parse light with exceptional temporal resolution. Here, we provide evidence for a single mechanism that allows ipRGCs to integrate over both time and wavelength. Light distributes the visual pigment, melanopsin, across three states, two silent and one signaling. Photoequilibration among states maintains pigment availability for sustained signaling, stability of the signaling state permits minutes-long temporal summation, and modest spectral separation of the silent states promotes uniform activation across wavelengths. By broadening the tuning of ipRGCs in both temporal and chromatic domains, melanopsin tristability produces signal integration for physiology and behavior." @default.
- W2023126912 created "2016-06-24" @default.
- W2023126912 creator A5018682017 @default.
- W2023126912 creator A5066711261 @default.
- W2023126912 date "2015-03-01" @default.
- W2023126912 modified "2023-10-15" @default.
- W2023126912 title "Melanopsin Tristability for Sustained and Broadband Phototransduction" @default.
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- W2023126912 doi "https://doi.org/10.1016/j.neuron.2015.02.011" @default.
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