Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023129087> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2023129087 abstract "Although several pathophysiological sequences, such as protease activation, free radical generation, and inflammatory mediator release, have been described in acute pancreatitis, the precise mechanism by which acute pancreatitis is initiated is unknown. Cellular calcium, a key physiological signaling element in cell function and also a crucial pathological intracellular messenger in cell injury, appears to be involved in the initiation and development of acute pancreatitis. The present study provides several lines of evidence supporting this suggestion. First, verapamil (a calcium channel blocker) administration was associated with a significant protection of rats from acute pancreatitis induced by high doses of cerulein (50 micrograms/kg/hr, subcutaneously), as evidenced both histologically and biochemically. Second, verapamil was found to minimize the increased tissue levels of calcium, platelet-activating factor, and thromboxane B2 detected during acute pancreatitis. Third, acute pancreatitis could be observed in rats with elevated serum calcium levels at low doses of cerulein (5 micrograms/kg/hr, subcutaneously), but could not be observed in rats with normal serum calcium levels treated with low doses of cerulein. It is proposed that cellular calcium, which is a critical signaling component in the synthesis and release of inflammatory mediators and several other events, may be an important factor in the pathogenesis of cerulein-induced acute pancreatitis." @default.
- W2023129087 created "2016-06-24" @default.
- W2023129087 creator A5004872137 @default.
- W2023129087 creator A5056416573 @default.
- W2023129087 creator A5064697412 @default.
- W2023129087 creator A5064934325 @default.
- W2023129087 creator A5072960859 @default.
- W2023129087 date "1996-01-01" @default.
- W2023129087 modified "2023-10-14" @default.
- W2023129087 title "Evidence for Altered Cellular Calcium in the Pathogenetic Mechanism of Acute Pancreatitis in Rats" @default.
- W2023129087 cites W117432842 @default.
- W2023129087 cites W1864830167 @default.
- W2023129087 cites W2022615718 @default.
- W2023129087 cites W2101748226 @default.
- W2023129087 cites W2116927690 @default.
- W2023129087 cites W2121385555 @default.
- W2023129087 cites W2282978544 @default.
- W2023129087 cites W2301197354 @default.
- W2023129087 doi "https://doi.org/10.1006/jsre.1996.0024" @default.
- W2023129087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8592406" @default.
- W2023129087 hasPublicationYear "1996" @default.
- W2023129087 type Work @default.
- W2023129087 sameAs 2023129087 @default.
- W2023129087 citedByCount "29" @default.
- W2023129087 countsByYear W20231290872012 @default.
- W2023129087 countsByYear W20231290872013 @default.
- W2023129087 countsByYear W20231290872015 @default.
- W2023129087 countsByYear W20231290872016 @default.
- W2023129087 countsByYear W20231290872020 @default.
- W2023129087 crossrefType "journal-article" @default.
- W2023129087 hasAuthorship W2023129087A5004872137 @default.
- W2023129087 hasAuthorship W2023129087A5056416573 @default.
- W2023129087 hasAuthorship W2023129087A5064697412 @default.
- W2023129087 hasAuthorship W2023129087A5064934325 @default.
- W2023129087 hasAuthorship W2023129087A5072960859 @default.
- W2023129087 hasConcept C126322002 @default.
- W2023129087 hasConcept C134018914 @default.
- W2023129087 hasConcept C181080969 @default.
- W2023129087 hasConcept C2775967933 @default.
- W2023129087 hasConcept C2776670229 @default.
- W2023129087 hasConcept C2777022698 @default.
- W2023129087 hasConcept C2780356492 @default.
- W2023129087 hasConcept C2780942790 @default.
- W2023129087 hasConcept C519063684 @default.
- W2023129087 hasConcept C71924100 @default.
- W2023129087 hasConcept C85520022 @default.
- W2023129087 hasConcept C98274493 @default.
- W2023129087 hasConceptScore W2023129087C126322002 @default.
- W2023129087 hasConceptScore W2023129087C134018914 @default.
- W2023129087 hasConceptScore W2023129087C181080969 @default.
- W2023129087 hasConceptScore W2023129087C2775967933 @default.
- W2023129087 hasConceptScore W2023129087C2776670229 @default.
- W2023129087 hasConceptScore W2023129087C2777022698 @default.
- W2023129087 hasConceptScore W2023129087C2780356492 @default.
- W2023129087 hasConceptScore W2023129087C2780942790 @default.
- W2023129087 hasConceptScore W2023129087C519063684 @default.
- W2023129087 hasConceptScore W2023129087C71924100 @default.
- W2023129087 hasConceptScore W2023129087C85520022 @default.
- W2023129087 hasConceptScore W2023129087C98274493 @default.
- W2023129087 hasLocation W20231290871 @default.
- W2023129087 hasLocation W20231290872 @default.
- W2023129087 hasOpenAccess W2023129087 @default.
- W2023129087 hasPrimaryLocation W20231290871 @default.
- W2023129087 hasRelatedWork W1788430129 @default.
- W2023129087 hasRelatedWork W2012790817 @default.
- W2023129087 hasRelatedWork W2016283973 @default.
- W2023129087 hasRelatedWork W2023129087 @default.
- W2023129087 hasRelatedWork W2025590009 @default.
- W2023129087 hasRelatedWork W2037982983 @default.
- W2023129087 hasRelatedWork W2074858950 @default.
- W2023129087 hasRelatedWork W2113845439 @default.
- W2023129087 hasRelatedWork W2402631745 @default.
- W2023129087 hasRelatedWork W4212774434 @default.
- W2023129087 isParatext "false" @default.
- W2023129087 isRetracted "false" @default.
- W2023129087 magId "2023129087" @default.
- W2023129087 workType "article" @default.