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• W2023130375 abstract "<h2>Abstract</h2><h3>Background context</h3> Tobacco smoking is a key risk factor for spine degeneration. However, the underlying mechanism by which smoking induces degeneration is not known. Recent studies implicate DNA damage as a cause of spine and intervertebral disc degeneration. Because tobacco smoke contains many genotoxins, we hypothesized that tobacco smoking promotes spine degeneration by inducing cellular DNA damage. <h3>Purpose</h3> To determine if DNA damage plays a causal role in smoking-induced spine degeneration. <h3>Study design</h3> To compare the effect of chronic tobacco smoke inhalation on intervertebral disc and vertebral bone in normal and DNA repair-deficient mice to determine the contribution of DNA damage to degenerative changes. <h3>Methods</h3> Two-month-old wild-type (C57BL/6) and DNA repair-deficient <i>Ercc1</i>^−/Δ mice were exposed to tobacco smoke by direct inhalation (4 cigarettes/day, 5 days/week for 7 weeks) to model first-hand smoking in humans. Total disc proteoglycan (PG) content (1,9-dimethylmethylene blue assay), PG synthesis (³⁵S-sulfate incorporation assay), aggrecan proteolysis (immunoblotting analysis), and vertebral bone morphology (microcomputed tomography) were measured. <h3>Results</h3> Exposure of wild-type mice to tobacco smoke led to a 19% increase in vertebral porosity and a 61% decrease in trabecular bone volume. Intervertebral discs of smoke-exposed animals also showed a 2.6-fold decrease in GAG content and an 8.1-fold decrease in new PG synthesis. These smoking-induced degenerative changes were similar but not worse in <i>Ercc1</i>^−/Δ mice. <h3>Conclusions</h3> Short-term exposure to high levels of primary tobacco smoke inhalation promotes degeneration of vertebral bone and discs. Disc degeneration is primarily driven by reduced synthesis of proteoglycans needed for vertebral cushioning. Degeneration was not exacerbated in congenic DNA repair-deficient mice, indicating that DNA damage per se does not have a significant causal role in driving smoke-induced spine degeneration." @default.
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• W2023130375 date "2014-03-01" @default.
• W2023130375 modified "2023-10-12" @default.
• W2023130375 title "Investigating the role of DNA damage in tobacco smoking-induced spine degeneration" @default.
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• W2023130375 doi "https://doi.org/10.1016/j.spinee.2013.08.034" @default.
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