FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023130443> ?p ?o ?g. }

• W2023130443 endingPage "1254" @default.
• W2023130443 startingPage "1249" @default.
• W2023130443 abstract "Acute activation of the hypothalamic-pituitary axis with CRH has been reported to suppress gonadotropin secretion in women of reproductive age. In this study we specifically examined the effects of increasing doses of human CRH (hCRH) on circulating concentrations of ACTH, cortisol, and gonadotropins in five agonadal women, aged 46–65 (mean, 51.2) yr. The subjects had undergone either natural menopause or surgical removal of their ovaries at least 1 yr before study. Each woman was studied on four separate occasions and received either saline or hCRH at a dose of 0.5, 1.0, or 2.0 μ/kg BW through an indwelling iv catheter in a randomized, single blind fashion. During each experiment, five sequential iv injections of the same dose of hCRH or saline were administered at 90-min intervals over an 8-h period, followed by a 10-μg iv bolus of GnRH to test for pituitary gonadotropin responsiveness. Blood samples for measurement of LH, FSH, PRL, ACTH, and cortisol were obtained at 15-min intervals through an indwelling iv in the contralateral arm. Episodic pulses of LH secretion were analyzed using the Cluster computer program. Transverse mean LH, FSH, and PRL levels did not change with increasing hCRH doses. Mean (±sem) LH pulse frequency [saline, 5.2 ± 0.4/8 h; hCRH, (0.5 μg/kg), 4.8 ± 0.2; hCRH (1 μg/kg), 5.2 ± 0.2; hCRH (2 μg/kg), 5.4 ± 0.2] and amplitude [saline, 14.4 ± 4.2 IU/L; hCRH (0.5 μg/kg), 14.0 ± 2.4; hCRH (1 μ/kg), 15.8 ± 2.5; hCRH (2 μg/kg), 17.2 ± 2.9] did not differ among groups. Although the transverse mean levels of ACTH [saline, 8.7 ± 0.2 pmol/L; hCRH (0.5 μg/kg), 12.4 ± 0.3; hCRH (1 μg/kg), 11.5 ± 0.4; hCRH (2 μg/kg), 12.8 ± 0.4] did not change with increasing doses of hCRH, the duration of cortisol peaks after hCRH was longer and accounted for the increased transverse mean at each dose [saline, 152.8 ± 4.1 nmol/L; hCRH (0.5 μg/kg), 265.4 ± 10.5; hCRH (1 μg/kg), 329.7 ± 14.3; hCRH (2 μg/kg), 348.2 ± 12.1]. These findings suggest that ever larger doses of pulsatile hCRH continue to increase adrenal output of cortisol secondary to more sustained ACTH responses. However, hCRH-induced acute hypercortisolism does not alter gonadotropin secretion in agonadal women." @default.
• W2023130443 created "2016-06-24" @default.
• W2023130443 creator A5053143151 @default.
• W2023130443 creator A5067441794 @default.
• W2023130443 creator A5074456277 @default.
• W2023130443 creator A5087336212 @default.
• W2023130443 creator A5091296451 @default.
• W2023130443 date "1991-06-01" @default.
• W2023130443 modified "2023-09-27" @default.
• W2023130443 title "Dose-Response Effects of Exogenous Pulsatile Human Corticotropin-Releasing Hormone on Adrenocorticotropin, Cortisol, and Gonadotropin Concentrations in Agonadal Women*" @default.
• W2023130443 cites W1529873354 @default.
• W2023130443 cites W1910488559 @default.
• W2023130443 cites W1972181075 @default.
• W2023130443 cites W1980354971 @default.
• W2023130443 cites W1992096020 @default.
• W2023130443 cites W2003414096 @default.
• W2023130443 cites W2005126283 @default.
• W2023130443 cites W2008742762 @default.
• W2023130443 cites W2028956297 @default.
• W2023130443 cites W2033213461 @default.
• W2023130443 cites W2038228594 @default.
• W2023130443 cites W2040583831 @default.
• W2023130443 cites W2046662261 @default.
• W2023130443 cites W2049002632 @default.
• W2023130443 cites W2060170224 @default.
• W2023130443 cites W2064273097 @default.
• W2023130443 cites W2064802376 @default.
• W2023130443 cites W2068948430 @default.
• W2023130443 cites W2072425282 @default.
• W2023130443 cites W2073388455 @default.
• W2023130443 cites W2083354311 @default.
• W2023130443 cites W2092610236 @default.
• W2023130443 cites W2097414936 @default.
• W2023130443 cites W2116374770 @default.
• W2023130443 cites W2147491023 @default.
• W2023130443 cites W2170893070 @default.
• W2023130443 cites W2171633312 @default.
• W2023130443 cites W38017655 @default.
• W2023130443 doi "https://doi.org/10.1210/jcem-72-6-1249" @default.
• W2023130443 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1851183" @default.
• W2023130443 hasPublicationYear "1991" @default.
• W2023130443 type Work @default.
• W2023130443 sameAs 2023130443 @default.
• W2023130443 citedByCount "27" @default.
• W2023130443 countsByYear W20231304432012 @default.
• W2023130443 countsByYear W20231304432014 @default.
• W2023130443 crossrefType "journal-article" @default.
• W2023130443 hasAuthorship W2023130443A5053143151 @default.
• W2023130443 hasAuthorship W2023130443A5067441794 @default.
• W2023130443 hasAuthorship W2023130443A5074456277 @default.
• W2023130443 hasAuthorship W2023130443A5087336212 @default.
• W2023130443 hasAuthorship W2023130443A5091296451 @default.
• W2023130443 hasConcept C126322002 @default.
• W2023130443 hasConcept C134018914 @default.
• W2023130443 hasConcept C2777397205 @default.
• W2023130443 hasConcept C2778782382 @default.
• W2023130443 hasConcept C43376680 @default.
• W2023130443 hasConcept C71315377 @default.
• W2023130443 hasConcept C71924100 @default.
• W2023130443 hasConceptScore W2023130443C126322002 @default.
• W2023130443 hasConceptScore W2023130443C134018914 @default.
• W2023130443 hasConceptScore W2023130443C2777397205 @default.
• W2023130443 hasConceptScore W2023130443C2778782382 @default.
• W2023130443 hasConceptScore W2023130443C43376680 @default.
• W2023130443 hasConceptScore W2023130443C71315377 @default.
• W2023130443 hasConceptScore W2023130443C71924100 @default.
• W2023130443 hasIssue "6" @default.
• W2023130443 hasLocation W20231304431 @default.
• W2023130443 hasLocation W20231304432 @default.
• W2023130443 hasOpenAccess W2023130443 @default.
• W2023130443 hasPrimaryLocation W20231304431 @default.
• W2023130443 hasRelatedWork W1997759048 @default.
• W2023130443 hasRelatedWork W2027210979 @default.
• W2023130443 hasRelatedWork W2037126054 @default.
• W2023130443 hasRelatedWork W2049266444 @default.
• W2023130443 hasRelatedWork W2066027832 @default.
• W2023130443 hasRelatedWork W2069420617 @default.
• W2023130443 hasRelatedWork W2072823512 @default.
• W2023130443 hasRelatedWork W2087941795 @default.
• W2023130443 hasRelatedWork W2135637476 @default.
• W2023130443 hasRelatedWork W2164661085 @default.
• W2023130443 hasVolume "72" @default.
• W2023130443 isParatext "false" @default.
• W2023130443 isRetracted "false" @default.
• W2023130443 magId "2023130443" @default.
• W2023130443 workType "article" @default.