FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023131277> ?p ?o ?g. }

• W2023131277 endingPage "426" @default.
• W2023131277 startingPage "419" @default.
• W2023131277 abstract "Zingerone, a major component found in ginger root, has been known as anti-mutagenic and anti-carcinogenic activities that are often associated with its anti-oxidative and anti-inflammatory activities. In recent studies, we examined molecular mechanism of zingerone treatment on pro-inflammatory NF-κB activation via the redox-related NIK/IKK and MAPK pathways. Action mechanism of zingerone on NF-κB signaling was investigated in aged rat kidney and endothelial cells. The results showed that zingerone had not only the antioxidant effect by constitutive suppression of ROS, but also anti-inflammatory effects by suppression of nuclear factor (NF)-κB activation in aged rat. In addition, zingerone treatment suppressed gene activation of pro-inflammatory enzymes, COX-2 and iNOS, which were upregulated with aging through NF-κB activation and IKK/MAPK signaling pathway. These experiments strongly indicate that zingerone treatment exerts a beneficial efficacy by suppressing both oxidative stress and age-related inflammation through the modulation of several key pro-inflammatory genes and transcription factors. Thus, the significance of our findings is that the zingerone treatment may provide some preventive measure against chronic inflammatory conditions that underlie many age-related inflammatory diseases, such as metabolic syndrome, cardiovascular disease, dementia, arthritis, diabetes, osteoprosis, and cancers." @default.
• W2023131277 created "2016-06-24" @default.
• W2023131277 creator A5004372903 @default.
• W2023131277 creator A5006872727 @default.
• W2023131277 creator A5018799075 @default.
• W2023131277 creator A5024862433 @default.
• W2023131277 creator A5028368667 @default.
• W2023131277 creator A5034103664 @default.
• W2023131277 creator A5035023285 @default.
• W2023131277 creator A5044134935 @default.
• W2023131277 creator A5047018041 @default.
• W2023131277 creator A5052838486 @default.
• W2023131277 creator A5054492574 @default.
• W2023131277 creator A5059068326 @default.
• W2023131277 creator A5063076347 @default.
• W2023131277 creator A5064363666 @default.
• W2023131277 creator A5070285940 @default.
• W2023131277 creator A5082525528 @default.
• W2023131277 creator A5082640425 @default.
• W2023131277 date "2010-06-01" @default.
• W2023131277 modified "2023-10-18" @default.
• W2023131277 title "Modulation of age-related NF-κB activation by dietary zingerone via MAPK pathway" @default.
• W2023131277 cites W1603048440 @default.
• W2023131277 cites W1975474301 @default.
• W2023131277 cites W1980267834 @default.
• W2023131277 cites W1986627544 @default.
• W2023131277 cites W1988617075 @default.
• W2023131277 cites W1993377197 @default.
• W2023131277 cites W2005019361 @default.
• W2023131277 cites W2006452078 @default.
• W2023131277 cites W2006642810 @default.
• W2023131277 cites W2012445085 @default.
• W2023131277 cites W2023401600 @default.
• W2023131277 cites W2032901533 @default.
• W2023131277 cites W2041952557 @default.
• W2023131277 cites W2045601200 @default.
• W2023131277 cites W2051806748 @default.
• W2023131277 cites W2051954664 @default.
• W2023131277 cites W2053836644 @default.
• W2023131277 cites W2056415482 @default.
• W2023131277 cites W2058494338 @default.
• W2023131277 cites W2072409295 @default.
• W2023131277 cites W2072661983 @default.
• W2023131277 cites W2082653051 @default.
• W2023131277 cites W2083228186 @default.
• W2023131277 cites W2085837280 @default.
• W2023131277 cites W2094539053 @default.
• W2023131277 cites W2110732115 @default.
• W2023131277 cites W2114426847 @default.
• W2023131277 cites W2143409915 @default.
• W2023131277 cites W2157942810 @default.
• W2023131277 cites W2163849426 @default.
• W2023131277 cites W2165555606 @default.
• W2023131277 cites W2169767676 @default.
• W2023131277 cites W2416415283 @default.
• W2023131277 cites W4232859895 @default.
• W2023131277 cites W85124676 @default.
• W2023131277 doi "https://doi.org/10.1016/j.exger.2010.03.005" @default.
• W2023131277 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20211236" @default.
• W2023131277 hasPublicationYear "2010" @default.
• W2023131277 type Work @default.
• W2023131277 sameAs 2023131277 @default.
• W2023131277 citedByCount "113" @default.
• W2023131277 countsByYear W20231312772012 @default.
• W2023131277 countsByYear W20231312772013 @default.
• W2023131277 countsByYear W20231312772014 @default.
• W2023131277 countsByYear W20231312772015 @default.
• W2023131277 countsByYear W20231312772016 @default.
• W2023131277 countsByYear W20231312772017 @default.
• W2023131277 countsByYear W20231312772018 @default.
• W2023131277 countsByYear W20231312772019 @default.
• W2023131277 countsByYear W20231312772020 @default.
• W2023131277 countsByYear W20231312772021 @default.
• W2023131277 countsByYear W20231312772022 @default.
• W2023131277 countsByYear W20231312772023 @default.
• W2023131277 crossrefType "journal-article" @default.
• W2023131277 hasAuthorship W2023131277A5004372903 @default.
• W2023131277 hasAuthorship W2023131277A5006872727 @default.
• W2023131277 hasAuthorship W2023131277A5018799075 @default.
• W2023131277 hasAuthorship W2023131277A5024862433 @default.
• W2023131277 hasAuthorship W2023131277A5028368667 @default.
• W2023131277 hasAuthorship W2023131277A5034103664 @default.
• W2023131277 hasAuthorship W2023131277A5035023285 @default.
• W2023131277 hasAuthorship W2023131277A5044134935 @default.
• W2023131277 hasAuthorship W2023131277A5047018041 @default.
• W2023131277 hasAuthorship W2023131277A5052838486 @default.
• W2023131277 hasAuthorship W2023131277A5054492574 @default.
• W2023131277 hasAuthorship W2023131277A5059068326 @default.
• W2023131277 hasAuthorship W2023131277A5063076347 @default.
• W2023131277 hasAuthorship W2023131277A5064363666 @default.
• W2023131277 hasAuthorship W2023131277A5070285940 @default.
• W2023131277 hasAuthorship W2023131277A5082525528 @default.
• W2023131277 hasAuthorship W2023131277A5082640425 @default.
• W2023131277 hasConcept C100175707 @default.
• W2023131277 hasConcept C104317684 @default.
• W2023131277 hasConcept C126322002 @default.
• W2023131277 hasConcept C127561419 @default.
• W2023131277 hasConcept C185592680 @default.

• next