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- W2023131823 abstract "Abstract Transection of the fimbria‐fornix bundle in adult rats results in degeneration of the septo‐hippocampal cholinergic pathway, reminiscent of that occurring in aging as well as Alzheimer disease. We report here a study of the effect of a treatment with acetyl‐ l ‐carnitine (ALCAR) in three‐month‐old Fischer 344 rats bearing a partial unilateral fimbria‐fornix transection. ALCAR is known to ameliorate some morphological and functional disturbances in the aged central nervous system (CNS). We used choline acetyltransferase (ChAT) and acetyl cholinesterase (AChE) as markers of central cholinergic function, and nerve growth factor (NGF) levels as indicative of the trophic regulation of the medio‐septal cholinergic system. ChAT and AChE activities were significantly reduced in the hippocampus (HIPP) ipsilateral to the lesion as compared to the contralateral one, while no changes were observed in the septum (SPT), nucleus basalis magnocellularis (NBM) or frontal cortex (FCX). ALCAR treatment restored ChAT activity in the ipsilateral HIPP, while AChE levels were not different from those of untreated animals, and did not affect NGF content in either SPT or HIPP." @default.
- W2023131823 created "2016-06-24" @default.
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- W2023131823 date "1995-02-01" @default.
- W2023131823 modified "2023-09-24" @default.
- W2023131823 title "Acetyl-<scp>l</scp>-carnitine restores choline acetyltransferase activity in the hippocampus of rats with partial unilateral fimbria-fornix transection" @default.
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- W2023131823 doi "https://doi.org/10.1016/0736-5748(94)00070-j" @default.
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