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- W2023132128 abstract "Abstract Folic acid induces a rapid transient increase in cellular cGMP levels in D. discoideum . A half-maximal cGMP response is effected by about 0.2 μM folate. In addition, extracellular folate is rapidly inactivated by deaminases. The main product 2-deaminofolic acid generates no measurable cGMP response at concentrations of up to 0.1 mM. At 1 mM a 10% response is observed. In contrast, 1 mM deaminofolic acid inhibits the cGMP accumulation as induced by 0.3 μM folic acid by 90%. This antagonism by deaminofolate is competitive with a K I value of 20 μM. When the cells are preincubated with deaminofolic acid before stimulation with folic acid, the inhibition changes to a non-competitive type ( K I = 20 μ M). It is concluded that although deaminofolate does not elicit cGMP accumulation, some cellular process is activated resulting in a diminished cGMP response to saturating folate stimuli. This process of desensitization is characterized by a first-order rate constant of 0.04 s −1 , while folic acid-induced desensitization proceeds with a higher rate of 0.6 s −1 . We discuss that the latter rate constant is more likely to reflect the rate of detection of a desensitizing signal, rather than the rate of the desensitization process itself." @default.
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- W2023132128 date "1986-07-01" @default.
- W2023132128 modified "2023-09-26" @default.
- W2023132128 title "2-Deaminofolic acid elicits desensitization without excitation of the cyclic GMP response in Dictyostelium discoideum" @default.
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- W2023132128 doi "https://doi.org/10.1016/0167-4889(86)90061-3" @default.
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