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- W2023132814 abstract "Serotonin-immunoreactive (5-HT-IR) nerve fibers observed in the pars intermedia and pars nervosa of the rat pituitary gland were examined after treatment of animals with antiserotonergic or anti-catecholaminergic drugs. p-Chlorophenylalanine, (PCPA), an inhibitor of 5-HT synthesis, eliminated staining in both areas of pituitary gland. p-Chloroamphetamine (PCA), a serotonin neurotoxin, did not produce a significant change in 5-HT-IR from control tissue. Unexpectedly, 6-hydroxydopamine (6-OHDA), a catecholamine neurotoxin, eliminated 5-HT staining in the pars intermedia, but not in the pars nervosa. These observations suggest that 5-HT present in fibers innervating the intermediate and neural lobes is synthesized in axons locally, or is taken up into fibers from extrinsic sources. In addition, catecholamines and 5-HT may co-exist in nerve terminals of both lobes of the pituitary gland." @default.
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- W2023132814 date "1986-03-01" @default.
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- W2023132814 title "Serotonin-immunoreactive nerve fibers of the rat pituitary: effects of anticatecholamine and antiserotonin drugs on staining patterns" @default.
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- W2023132814 doi "https://doi.org/10.1016/0006-8993(86)90575-5" @default.
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