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• W2023132914 abstract "A Purkinje cell-specific transgene, L7-lacZ, is expressed in a series of parasagitally oriented stripes in the mouse cerebellum. This banding pattern can be perturbed by promoter mutation, showing that a combination of positive and negative control elements contributes to the temporal and spatial map of L7 gene expression. In addition to the parasagittal stripes, certain mutations reveal Purkinje cells organized into compartments oriented in the transverse plane of the cerebellum. Transcription factors of the POU or homeobox families appear to be involved in controlling L7 expression in the transverse orientation. Strikingly, some of the domains of gene expression revealed by the mutations appear to correspond to functional compartments of Purkinje cells, thereby suggesting an underlying genetic principle used to orchestrate functional organization in the nervous system." @default.
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• W2023132914 date "1993-06-01" @default.
• W2023132914 modified "2023-10-16" @default.
• W2023132914 title "Control of segment-like patterns of gene expression in the mouse cerebellum" @default.
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• W2023132914 doi "https://doi.org/10.1016/0896-6273(93)90050-2" @default.
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