FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023133235> ?p ?o ?g. }

• W2023133235 endingPage "22987" @default.
• W2023133235 startingPage "22978" @default.
• W2023133235 abstract "A uniquely sensitive method for ceramide domain detection allowed us to study in detail cholesterol-ceramide interactions in lipid bilayers with low (physiological) ceramide concentrations, ranging from low or no cholesterol (a situation similar to intracellular membranes, such as endoplasmic reticulum) to high cholesterol (similar to mammalian plasma membrane). Diverse fluorescence spectroscopy and microscopy experiments were conducted showing that for low cholesterol amounts ceramide segregates into gel domains that disappear upon increasing cholesterol levels. This was observed in different raft (sphingomyelin/cholesterol-containing) and non-raft (sphingomyelin-absent) membranes, i.e. mimicking different types of cell membranes. Cholesterol-ceramide interactions have been described mainly as raft sphingomyelin-dependent. Here sphingomyelin independence is demonstrated. In addition, ceramide-rich domains re-appear when either cholesterol is converted by cholesterol oxidase to cholestenone or the temperature is decreased. Ceramide is more soluble in cholesterol-rich fluid membranes than in cholesterol-poor ones, thereby increasing the chemical potential of cholesterol. Ceramide solubility depends on the average gel-fluid transition temperature of the remaining membrane lipids. The inability of cholestenone-rich membranes to dissolve ceramide gel domains shows that the cholesterol ordering and packing properties are fundamental to the mixing process. We also show that the solubility of cholesterol in ceramide domains is low. The results are rationalized by a ternary phospholipid/ceramide/cholesterol phase diagram, providing the framework for the better understanding of biochemical phenomena modulated by cholesterol-ceramide interactions such as cholesterol oxidase activity, lipoprotein metabolism, and lipid targeting in cancer therapy. It also suggests that the lipid compositions of different organelles are such that ceramide gel domains are not formed unless a stress or pathological situation occurs." @default.
• W2023133235 created "2016-06-24" @default.
• W2023133235 creator A5001302202 @default.
• W2023133235 creator A5003185357 @default.
• W2023133235 creator A5030458055 @default.
• W2023133235 creator A5048872989 @default.
• W2023133235 creator A5087922737 @default.
• W2023133235 date "2009-08-01" @default.
• W2023133235 modified "2023-10-18" @default.
• W2023133235 title "Cholesterol-rich Fluid Membranes Solubilize Ceramide Domains" @default.
• W2023133235 cites W1564861448 @default.
• W2023133235 cites W1966452335 @default.
• W2023133235 cites W1972925786 @default.
• W2023133235 cites W1974282614 @default.
• W2023133235 cites W1974928798 @default.
• W2023133235 cites W1975672381 @default.
• W2023133235 cites W1981072031 @default.
• W2023133235 cites W1988201012 @default.
• W2023133235 cites W1988215270 @default.
• W2023133235 cites W1988610754 @default.
• W2023133235 cites W1990700312 @default.
• W2023133235 cites W1995515519 @default.
• W2023133235 cites W1995999417 @default.
• W2023133235 cites W1997156303 @default.
• W2023133235 cites W1998634209 @default.
• W2023133235 cites W2002244693 @default.
• W2023133235 cites W2004315725 @default.
• W2023133235 cites W2007320109 @default.
• W2023133235 cites W2011925577 @default.
• W2023133235 cites W2012693613 @default.
• W2023133235 cites W2018375585 @default.
• W2023133235 cites W2018622490 @default.
• W2023133235 cites W2019164398 @default.
• W2023133235 cites W2023125175 @default.
• W2023133235 cites W2027685072 @default.
• W2023133235 cites W2028333033 @default.
• W2023133235 cites W2028692387 @default.
• W2023133235 cites W2030400425 @default.
• W2023133235 cites W2032984448 @default.
• W2023133235 cites W2038815148 @default.
• W2023133235 cites W2039552793 @default.
• W2023133235 cites W2042284982 @default.
• W2023133235 cites W2048689532 @default.
• W2023133235 cites W2048751065 @default.
• W2023133235 cites W2051818991 @default.
• W2023133235 cites W2055470772 @default.
• W2023133235 cites W2059246206 @default.
• W2023133235 cites W2064210924 @default.
• W2023133235 cites W2068592796 @default.
• W2023133235 cites W2092735428 @default.
• W2023133235 cites W2093354310 @default.
• W2023133235 cites W2096044777 @default.
• W2023133235 cites W2100799417 @default.
• W2023133235 cites W2103194139 @default.
• W2023133235 cites W2110869255 @default.
• W2023133235 cites W2112237647 @default.
• W2023133235 cites W2114557817 @default.
• W2023133235 cites W2115025939 @default.
• W2023133235 cites W2115507762 @default.
• W2023133235 cites W2126544407 @default.
• W2023133235 cites W2126646352 @default.
• W2023133235 cites W2133991651 @default.
• W2023133235 cites W2142300557 @default.
• W2023133235 cites W2151603054 @default.
• W2023133235 cites W2153022420 @default.
• W2023133235 cites W2156892356 @default.
• W2023133235 cites W2170885541 @default.
• W2023133235 cites W2345229174 @default.
• W2023133235 cites W2345312306 @default.
• W2023133235 cites W81206062 @default.
• W2023133235 doi "https://doi.org/10.1074/jbc.m109.026567" @default.
• W2023133235 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2755705" @default.
• W2023133235 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19520848" @default.
• W2023133235 hasPublicationYear "2009" @default.
• W2023133235 type Work @default.
• W2023133235 sameAs 2023133235 @default.
• W2023133235 citedByCount "130" @default.
• W2023133235 countsByYear W20231332352012 @default.
• W2023133235 countsByYear W20231332352013 @default.
• W2023133235 countsByYear W20231332352014 @default.
• W2023133235 countsByYear W20231332352015 @default.
• W2023133235 countsByYear W20231332352016 @default.
• W2023133235 countsByYear W20231332352017 @default.
• W2023133235 countsByYear W20231332352018 @default.
• W2023133235 countsByYear W20231332352019 @default.
• W2023133235 countsByYear W20231332352020 @default.
• W2023133235 countsByYear W20231332352021 @default.
• W2023133235 countsByYear W20231332352022 @default.
• W2023133235 countsByYear W20231332352023 @default.
• W2023133235 crossrefType "journal-article" @default.
• W2023133235 hasAuthorship W2023133235A5001302202 @default.
• W2023133235 hasAuthorship W2023133235A5003185357 @default.
• W2023133235 hasAuthorship W2023133235A5030458055 @default.
• W2023133235 hasAuthorship W2023133235A5048872989 @default.
• W2023133235 hasAuthorship W2023133235A5087922737 @default.
• W2023133235 hasBestOaLocation W20231332351 @default.
• W2023133235 hasConcept C158617107 @default.
• W2023133235 hasConcept C185592680 @default.

• next