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- W2023134404 abstract "1 Systemic (s.c. or p.o.) administration of l-threo-3,4-dihydroxyphenylserine (droxidopa, l-threo-DOPS; l-threo-3,4-dihydroxyphenylserine (droxidopa, l-threo-DOPS, l-DOPS); noradrenaline precursor; antinociception; analgesia; α-adrenoceptors; l-aromatic amino acid decarboxylase 2 Antinociception elicited by l-DOPS (400 mg kg−1, s.c.) was not affected by s.c. injection of benserazide, a peripherally preferential l-aromatic amino acid decarboxylase inhibitor, but was suppressed by its intracerebroventricular (i.c.v.) injection. 3 I.c.v. or intrathecal (i.t.) administration of the non-selective α-blocker, phentolamine, significantly reduced l-DOPS-induced antinociception. 4 I.c.v. administration of the α1-blocker, prazosin, but not the α2-blocker, yohimbine, abolished the antinociceptive effects of l-DOPS. In contrast, both blockers, when administered i.t., exhibited significant inhibitory effects. 5 These results suggest that systemic l-DOPS produces opioid-independent antinociception, mediated by supraspinal α1-adrenoceptors and by spinal α1- and α2-adrenoceptors and may predict additional therapeutic applications of l-DOPS as an analgesic." @default.
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- W2023134404 date "1994-02-01" @default.
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- W2023134404 title "The noradrenaline precursor l-threo-3,4-dihydroxyphenylserine exhibits antinociceptive activity via central α-adrenoceptors in the mouse" @default.
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- W2023134404 doi "https://doi.org/10.1111/j.1476-5381.1994.tb14765.x" @default.
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