Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023135059> ?p ?o ?g. }
- W2023135059 endingPage "055102" @default.
- W2023135059 startingPage "055102" @default.
- W2023135059 abstract "To reduce the side effects and drug resistance in cancer chemotherapy, we have examined the in vitro efficacy of the combination of paclitaxel (PTX) and doxorubicin (DOX) loaded in nanosized polymeric micelles with glycolipid-like structure, which formed by lipid grafted chitosan. The cytotoxicities of PTX and DOX, either as single agents or in combination, were examined using drug sensitive tumor cells and drug resistant cells. It was found that the 50% inhibition of cellular growth (IC(50)) of PTX and DOX in micelles against drug sensitive cells was lowered about 20-fold and 4-7-fold compared to that of Taxol and DOX solution, respectively. The IC(50) of PTX and DOX in micelles against drug resistant cells was lowered more significantly, and no clear difference was found between drug sensitive and drug resistant cells. The coadministration of PTX and DOX in micelles showed a more conspicuous effect than that of micelles loaded with a single drug. The micelles presented excellent internalization to cancer cells, which results in increased intracellular accumulation of PTX and DOX in its molecular-target site. The coadministration of glycolipid-like micelles loaded with different cytotoxic drugs indicated synergistic effects for drug sensitive cells and drug resistant cells." @default.
- W2023135059 created "2016-06-24" @default.
- W2023135059 creator A5010773627 @default.
- W2023135059 creator A5015921335 @default.
- W2023135059 creator A5023586508 @default.
- W2023135059 creator A5033237183 @default.
- W2023135059 creator A5056949279 @default.
- W2023135059 creator A5068911085 @default.
- W2023135059 creator A5071751871 @default.
- W2023135059 date "2009-01-09" @default.
- W2023135059 modified "2023-10-16" @default.
- W2023135059 title "Coadministration of glycolipid-like micelles loading cytotoxic drug with different action site for efficient cancer chemotherapy" @default.
- W2023135059 cites W1585404684 @default.
- W2023135059 cites W1968931590 @default.
- W2023135059 cites W1978816171 @default.
- W2023135059 cites W1982542571 @default.
- W2023135059 cites W1983546164 @default.
- W2023135059 cites W1985882425 @default.
- W2023135059 cites W1994658395 @default.
- W2023135059 cites W1994941022 @default.
- W2023135059 cites W2001286327 @default.
- W2023135059 cites W2003420178 @default.
- W2023135059 cites W2003495186 @default.
- W2023135059 cites W2004829858 @default.
- W2023135059 cites W2006434892 @default.
- W2023135059 cites W2012479775 @default.
- W2023135059 cites W2018693859 @default.
- W2023135059 cites W2025449975 @default.
- W2023135059 cites W2033346155 @default.
- W2023135059 cites W2035112669 @default.
- W2023135059 cites W2038061816 @default.
- W2023135059 cites W2059877047 @default.
- W2023135059 cites W2061881089 @default.
- W2023135059 cites W2062047808 @default.
- W2023135059 cites W2084448745 @default.
- W2023135059 cites W2090075420 @default.
- W2023135059 cites W2098142549 @default.
- W2023135059 cites W2112518808 @default.
- W2023135059 cites W2118878458 @default.
- W2023135059 cites W2125955976 @default.
- W2023135059 cites W2164833579 @default.
- W2023135059 cites W2329100947 @default.
- W2023135059 cites W38682668 @default.
- W2023135059 cites W4255152173 @default.
- W2023135059 cites W4255246690 @default.
- W2023135059 doi "https://doi.org/10.1088/0957-4484/20/5/055102" @default.
- W2023135059 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19417333" @default.
- W2023135059 hasPublicationYear "2009" @default.
- W2023135059 type Work @default.
- W2023135059 sameAs 2023135059 @default.
- W2023135059 citedByCount "20" @default.
- W2023135059 countsByYear W20231350592012 @default.
- W2023135059 countsByYear W20231350592013 @default.
- W2023135059 countsByYear W20231350592014 @default.
- W2023135059 countsByYear W20231350592015 @default.
- W2023135059 countsByYear W20231350592016 @default.
- W2023135059 countsByYear W20231350592018 @default.
- W2023135059 countsByYear W20231350592019 @default.
- W2023135059 countsByYear W20231350592022 @default.
- W2023135059 countsByYear W20231350592023 @default.
- W2023135059 crossrefType "journal-article" @default.
- W2023135059 hasAuthorship W2023135059A5010773627 @default.
- W2023135059 hasAuthorship W2023135059A5015921335 @default.
- W2023135059 hasAuthorship W2023135059A5023586508 @default.
- W2023135059 hasAuthorship W2023135059A5033237183 @default.
- W2023135059 hasAuthorship W2023135059A5056949279 @default.
- W2023135059 hasAuthorship W2023135059A5068911085 @default.
- W2023135059 hasAuthorship W2023135059A5071751871 @default.
- W2023135059 hasConcept C11268172 @default.
- W2023135059 hasConcept C121608353 @default.
- W2023135059 hasConcept C126322002 @default.
- W2023135059 hasConcept C139770010 @default.
- W2023135059 hasConcept C1491633281 @default.
- W2023135059 hasConcept C154317977 @default.
- W2023135059 hasConcept C178790620 @default.
- W2023135059 hasConcept C184651966 @default.
- W2023135059 hasConcept C185592680 @default.
- W2023135059 hasConcept C192562407 @default.
- W2023135059 hasConcept C202751555 @default.
- W2023135059 hasConcept C22222904 @default.
- W2023135059 hasConcept C2776694085 @default.
- W2023135059 hasConcept C2777292972 @default.
- W2023135059 hasConcept C2780035454 @default.
- W2023135059 hasConcept C2781303535 @default.
- W2023135059 hasConcept C55493867 @default.
- W2023135059 hasConcept C71924100 @default.
- W2023135059 hasConcept C96232424 @default.
- W2023135059 hasConcept C98274493 @default.
- W2023135059 hasConceptScore W2023135059C11268172 @default.
- W2023135059 hasConceptScore W2023135059C121608353 @default.
- W2023135059 hasConceptScore W2023135059C126322002 @default.
- W2023135059 hasConceptScore W2023135059C139770010 @default.
- W2023135059 hasConceptScore W2023135059C1491633281 @default.
- W2023135059 hasConceptScore W2023135059C154317977 @default.
- W2023135059 hasConceptScore W2023135059C178790620 @default.
- W2023135059 hasConceptScore W2023135059C184651966 @default.
- W2023135059 hasConceptScore W2023135059C185592680 @default.
- W2023135059 hasConceptScore W2023135059C192562407 @default.