FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023135934> ?p ?o ?g. }

• W2023135934 endingPage "937" @default.
• W2023135934 startingPage "929" @default.
• W2023135934 abstract "The vulnerability of different dopaminergic cell populations to damage caused by the herbicide paraquat was assessed by stereological counts of tyrosine hydroxylase-positive and calbindin-D28k-immunoreactive neurons in A9 (substantia nigra pars compacta) and A10 (ventral tegmental area and other cell groups). In saline-treated control mice, tyrosine hydroxylase-immunoreactive neurons represented 80% and 45% of the total neuronal population in A9 and A10, respectively, and the number of calbindin-D28k-positive neurons was five times greater in A10 than A9. Sequential injections with paraquat resulted in a significant loss of dopaminergic neurons in A9. In contrast, tyrosine hydroxylase-positive cells in A10 were spared from paraquat-induced degeneration. Furthermore, expression of calbindin-D28k was consistently associated with neuronal resistance to the herbicide in both A9 and A10. Paraquat exposure also induced oxidative stress as indicated by an increase in the number of midbrain cells positive for 4-hydroxy-2-nonenal, a marker of lipid peroxidation. Co-localization studies revealed that calbindin-D28k immunoreactivity overlapped with tyrosine hydroxylase labeling and that, after paraquat administration, (i) the vast majority of midbrain 4-hydroxy-2-nonenal-immunoreactive cells were dopaminergic (tyrosine hydroxylase-immunoreactive), (ii) tyrosine hydroxylase/4-hydroxy-2-nonenal-positive neurons were much more prevalent in A9 than A10, and (iii) all calbindin-D28k-containing neurons were characterized by lack of lipid peroxidation (4-hydroxy-2-nonenal immunoreactivity). Results in this paraquat model emphasize that, despite sharing a similar dopaminergic phenotype, different groups of midbrain neurons vary dramatically in their vulnerability to injury. Data also indicate that these differences are attributable, at least in part, to a varying susceptibility of dopaminergic cell populations to oxidative stress." @default.
• W2023135934 created "2016-06-24" @default.
• W2023135934 creator A5010159066 @default.
• W2023135934 creator A5035849217 @default.
• W2023135934 creator A5058276075 @default.
• W2023135934 creator A5090663988 @default.
• W2023135934 date "2006-01-01" @default.
• W2023135934 modified "2023-10-12" @default.
• W2023135934 title "Decreased susceptibility to oxidative stress underlies the resistance of specific dopaminergic cell populations to paraquat-induced degeneration" @default.
• W2023135934 cites W1522890520 @default.
• W2023135934 cites W1546975896 @default.
• W2023135934 cites W1578882407 @default.
• W2023135934 cites W1591724033 @default.
• W2023135934 cites W1970556285 @default.
• W2023135934 cites W1970846389 @default.
• W2023135934 cites W1984226833 @default.
• W2023135934 cites W1991262316 @default.
• W2023135934 cites W1992673078 @default.
• W2023135934 cites W1993005324 @default.
• W2023135934 cites W2010395737 @default.
• W2023135934 cites W2011226249 @default.
• W2023135934 cites W2020211228 @default.
• W2023135934 cites W2024063933 @default.
• W2023135934 cites W2030326240 @default.
• W2023135934 cites W2041037585 @default.
• W2023135934 cites W2043899667 @default.
• W2023135934 cites W2043990301 @default.
• W2023135934 cites W2054421268 @default.
• W2023135934 cites W2060181203 @default.
• W2023135934 cites W2079536916 @default.
• W2023135934 cites W2095323303 @default.
• W2023135934 cites W2110961391 @default.
• W2023135934 cites W2169622817 @default.
• W2023135934 cites W274893284 @default.
• W2023135934 cites W62603772 @default.
• W2023135934 doi "https://doi.org/10.1016/j.neuroscience.2006.03.069" @default.
• W2023135934 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16677770" @default.
• W2023135934 hasPublicationYear "2006" @default.
• W2023135934 type Work @default.
• W2023135934 sameAs 2023135934 @default.
• W2023135934 citedByCount "65" @default.
• W2023135934 countsByYear W20231359342012 @default.
• W2023135934 countsByYear W20231359342013 @default.
• W2023135934 countsByYear W20231359342014 @default.
• W2023135934 countsByYear W20231359342015 @default.
• W2023135934 countsByYear W20231359342016 @default.
• W2023135934 countsByYear W20231359342017 @default.
• W2023135934 countsByYear W20231359342018 @default.
• W2023135934 countsByYear W20231359342019 @default.
• W2023135934 countsByYear W20231359342020 @default.
• W2023135934 countsByYear W20231359342021 @default.
• W2023135934 countsByYear W20231359342022 @default.
• W2023135934 crossrefType "journal-article" @default.
• W2023135934 hasAuthorship W2023135934A5010159066 @default.
• W2023135934 hasAuthorship W2023135934A5035849217 @default.
• W2023135934 hasAuthorship W2023135934A5058276075 @default.
• W2023135934 hasAuthorship W2023135934A5090663988 @default.
• W2023135934 hasConcept C126322002 @default.
• W2023135934 hasConcept C134018914 @default.
• W2023135934 hasConcept C137183658 @default.
• W2023135934 hasConcept C159167319 @default.
• W2023135934 hasConcept C26265296 @default.
• W2023135934 hasConcept C2776151105 @default.
• W2023135934 hasConcept C2776527163 @default.
• W2023135934 hasConcept C2776773494 @default.
• W2023135934 hasConcept C2780829032 @default.
• W2023135934 hasConcept C2780938664 @default.
• W2023135934 hasConcept C2780948874 @default.
• W2023135934 hasConcept C513476851 @default.
• W2023135934 hasConcept C519063684 @default.
• W2023135934 hasConcept C55493867 @default.
• W2023135934 hasConcept C71924100 @default.
• W2023135934 hasConcept C86803240 @default.
• W2023135934 hasConceptScore W2023135934C126322002 @default.
• W2023135934 hasConceptScore W2023135934C134018914 @default.
• W2023135934 hasConceptScore W2023135934C137183658 @default.
• W2023135934 hasConceptScore W2023135934C159167319 @default.
• W2023135934 hasConceptScore W2023135934C26265296 @default.
• W2023135934 hasConceptScore W2023135934C2776151105 @default.
• W2023135934 hasConceptScore W2023135934C2776527163 @default.
• W2023135934 hasConceptScore W2023135934C2776773494 @default.
• W2023135934 hasConceptScore W2023135934C2780829032 @default.
• W2023135934 hasConceptScore W2023135934C2780938664 @default.
• W2023135934 hasConceptScore W2023135934C2780948874 @default.
• W2023135934 hasConceptScore W2023135934C513476851 @default.
• W2023135934 hasConceptScore W2023135934C519063684 @default.
• W2023135934 hasConceptScore W2023135934C55493867 @default.
• W2023135934 hasConceptScore W2023135934C71924100 @default.
• W2023135934 hasConceptScore W2023135934C86803240 @default.
• W2023135934 hasIssue "2" @default.
• W2023135934 hasLocation W20231359341 @default.
• W2023135934 hasLocation W20231359342 @default.
• W2023135934 hasOpenAccess W2023135934 @default.
• W2023135934 hasPrimaryLocation W20231359341 @default.
• W2023135934 hasRelatedWork W2027256318 @default.
• W2023135934 hasRelatedWork W2032628806 @default.
• W2023135934 hasRelatedWork W2046764643 @default.
• W2023135934 hasRelatedWork W2047685096 @default.

• next